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A new sesquiterpene from the leaves of Cornus officinalis and their potential neuroprotective activities
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Jing-ke ZHANG1, 2, Deng-hui ZHU1, 2, Meng LI1, 2, Shuang-shuang XIE1, 2, Meng-nan ZENG1, 2, Xiao-ke ZHENG1, 2, *, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(4) : 1041 - 1045
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Acta Pharmaceutica Sinica | 2025, 60(4): 1041-1045
Original Articles
A new sesquiterpene from the leaves of Cornus officinalis and their potential neuroprotective activities
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Jing-ke ZHANG1, 2, Deng-hui ZHU1, 2, Meng LI1, 2, Shuang-shuang XIE1, 2, Meng-nan ZENG1, 2, Xiao-ke ZHENG1, 2, *, Wei-sheng FENG1, 2, *
Affiliations
  • 1Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2025-04-12 doi: 10.16438/j.0513-4870.2024-0847
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Five sesquiterpenoids were isolated from a 50% acetone extract of Cornus officinalis leaves, a traditional non-medicinal part of Cornus officinalis, using modern column chromatographic techniques such as macroporous adsorbent resins colum, silica gel colum, chromatography gel colum and semi-preparative liquid chromatography techniques. Their structures were identified by modern wave spectroscopy techniques and electronic circular dichroism (ECD) and assigned as cornurtone A (1), cornucadinoside B (2), lacinilene C (3), 3, 12-dihydroxycadalene (4), cornucadinoside C (5). Compound 1 was new compound and compounds 2-5 were first isolated from leaves of Cornus officinalis. Compounds 2 and 3 had potential neuroprotective activities.

Cornus officinalis leaf  /  sesquiterpene  /  structure identification  /  neuroprotective activity
Jing-ke ZHANG, Deng-hui ZHU, Meng LI, Shuang-shuang XIE, Meng-nan ZENG, Xiao-ke ZHENG, Wei-sheng FENG. A new sesquiterpene from the leaves of Cornus officinalis and their potential neuroprotective activities[J]. Acta Pharmaceutica Sinica, 2025 , 60 (4) : 1041 -1045 . DOI: 10.16438/j.0513-4870.2024-0847
Year 2025 volume 60 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2024-0847
  • Receive Date:2024-09-02
  • Online Date:2025-10-29
  • Published:2025-04-12
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  • Received:2024-09-02
  • Revised:2025-01-13
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    1Henan University of Chinese Medicine, Zhengzhou 450046, China
    2The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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