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Anti-renal fibrosis activity screening was performed on the extracts of Liquidambar formosana via the activity-tracing approach, which led to the identification of the bioactive fractions. Subsequent separation and purification afforded seven abietane-type diterpenoids, including one new diterpenoid, liquidformosane A (1) and six known ones. The planar structure of the new compound was established by nuclear magnetic resonance spectroscopy (NMR), and its stereoconfiguration was confirmed by quantum chemical calculations for simulation and prediction of electronic circular dichroism (ECD) spectra. The Western blot method was used to evaluate the in vitro anti-renal fibrosis activity of compounds 1-7, and the results showed that compounds 5-7 all exhibited significant anti-renal fibrosis activity.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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