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A total of seven furan natural products were isolated from the ethyl acetate extract of the fermentation product of the mycelium of Cordyceps militaris through a combination of chromatographic techniques, including silica gel column chromatography and semi-preparative HPLC. Based on their physicochemical properties and spectroscopic data, the structures of isolated compounds were identified as ethyl 5-[(3R)-hydroxybutyl]-2-furanacetate (1), 5-[(3R)-hydroxybutyl]-2-furancarboxylic acid (2), methyl 5-[(3R)-hydroxybutanoyl]-2-furanacetate (3), 5-[(3R)-hydroxybutyl]-2-furancarboxaldehyde (4), methyl 5-(2-hydroxyethyl)-2-furanacetate (5), 5-[(3R)-hydroxybutyl]-2-furanacetic acid (6), and methyl 5-[(3R)-hydroxybutyl]-2-furanacetate (7). Among them, compounds 1-3 were new compounds, compound 4 and 5 represents a new natural product, and compound 6 and 7 were isolated from Cordyceps militaris for the first time. Compounds 1 and 3-7 exhibited anti-inflammatory activity in varying degrees and significantly inhibited nitric oxide production in lipopolysaccharide-induced mouse mononuclear macrophage RAW264.7 cell line. Compound 2 showed some cytotoxic activity against Spodoptera frugiperda ovarian Sf9 cells with an IC50 value of 57.01 μmol·L-1.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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