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Research progress on the regulatory effects of alkaloids on the immune system and its mechanisms
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Shu-rong ZHANG, Yi-ming BAI, Cai-qin YAN, Yi-heng CHEN, Zhe WANG, Ai-lin LIU*
Acta Pharmaceutica Sinica | 2026, 61(8) : 2840 - 2857
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Acta Pharmaceutica Sinica | 2026, 61(8): 2840-2857
• Reviews •
Research progress on the regulatory effects of alkaloids on the immune system and its mechanisms
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Shu-rong ZHANG, Yi-ming BAI, Cai-qin YAN, Yi-heng CHEN, Zhe WANG, Ai-lin LIU*
Affiliations
  • Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Published: 2026-08-12 doi: 10.16438/j.0513-4870.2026-0150
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As significant bioactive constituents within natural products, alkaloids exhibit characteristics of extensive sources, diverse structures, multi-targeted and multi-level actions, and possess potent immunomodulatory effects. Although numerous studies have explored the pharmacological effects and mechanisms of alkaloids, a systematic review of their immunomodulatory activities and underlying mechanisms remains to be systematically reviewed, particularly an integrative analysis of the most recent research advances. Therefore, this paper collates recent research findings on alkaloids within the field of immunoregulation. It reviews the modulatory effects of alkaloids on the immune system, summarises the principal molecular mechanisms underlying their actions, and outlines their applications in the treatment of immune-related diseases. This review aims to provide a reference for subsequent mechanistic studies and the development of related pharmaceuticals.

alkaloid  /  natural product  /  immune regulation  /  mechanism of action  /  research progress
张书荣, 白祎名, 颜彩琴, 陈毅恒, 王喆, 刘艾林. 生物碱对免疫系统的调节作用及其机制研究进展. 药学学报, 2026 , 61 (8) : 2840 -2857 . DOI: 10.16438/j.0513-4870.2026-0150
Shu-rong ZHANG, Yi-ming BAI, Cai-qin YAN, Yi-heng CHEN, Zhe WANG, Ai-lin LIU. Research progress on the regulatory effects of alkaloids on the immune system and its mechanisms[J]. Acta Pharmaceutica Sinica, 2026 , 61 (8) : 2840 -2857 . DOI: 10.16438/j.0513-4870.2026-0150
Year 2026 volume 61 Issue 8
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108
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doi: 10.16438/j.0513-4870.2026-0150
  • Receive Date:2026-02-03
  • Online Date:2026-09-21
  • Published:2026-08-12
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  • Received:2026-02-03
  • Revised:2026-04-25
Affiliations
    Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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