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Recent advances in the biological activities of 1,3,5-triazine derivatives
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Meng-yuan WANG1, 2, Yu-meng HAO2, Da-zhi ZHANG2, Xiao-bo WANG1, *, Fei XIE2, *
Acta Pharmaceutica Sinica | 2026, 61(8) : 2879 - 2896
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Acta Pharmaceutica Sinica | 2026, 61(8): 2879-2896
• Reviews •
Recent advances in the biological activities of 1,3,5-triazine derivatives
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Meng-yuan WANG1, 2, Yu-meng HAO2, Da-zhi ZHANG2, Xiao-bo WANG1, *, Fei XIE2, *
Affiliations
  • 1School of Chinese Materia Medic, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2School of Pharmacy, Naval Medical University, Shanghai 200433, China
Published: 2026-08-12 doi: 10.16438/j.0513-4870.2026-0051
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As a prominent class of nitrogen-containing heterocycles, 1,3,5-triazines are characterized by their rigid, symmetrical structures, ease of functionalization, exceptional biological activities, making them a privileged scaffold in medicinal chemistry. This paper provides a systematic review of the research progress on 1,3,5-triazine derivatives over the past five years (2021-2025), covering their structure-activity relationships and mechanisms of action. Results indicate that 1,3,5-triazine compounds exhibit promising antimicrobial activity against methicillin-resistant Staphylococcus aureus, drug-resistant Escherichia coli, and Candida albicans. Furthermore, certain 1,3,5-triazine compounds target PD-L1, PI3K/mTOR, or EGFR, thereby inducing apoptosis or cell cycle arrest and inhibiting tumor cell growth. In addition, these compounds also have anticonvulsant, neuroprotective, antimalarial, antihyperglycemic, and anti-inflammatory properties. However, several 1,3,5-triazine compounds lack clear mechanisms and possess unsatisfactory efficacy, requiring further in-depth research to develop new chemical entities.

1,3,5-triazine  /  biological activity  /  antimicrobial  /  antitumor  /  research advance
王梦园, 郝雨濛, 张大志, 王晓波, 谢斐. 1,3,5-三嗪类化合物生物活性研究进展. 药学学报, 2026 , 61 (8) : 2879 -2896 . DOI: 10.16438/j.0513-4870.2026-0051
Meng-yuan WANG, Yu-meng HAO, Da-zhi ZHANG, Xiao-bo WANG, Fei XIE. Recent advances in the biological activities of 1,3,5-triazine derivatives[J]. Acta Pharmaceutica Sinica, 2026 , 61 (8) : 2879 -2896 . DOI: 10.16438/j.0513-4870.2026-0051
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Year 2026 volume 61 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2026-0051
  • Receive Date：2026-01-13
  • Online Date：2026-09-21
  • Published：2026-08-12
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History
  • Received：2026-01-13
  • Revised：2026-03-22
Affiliations
    1School of Chinese Materia Medic, Shenyang Pharmaceutical University, Shenyang 110016, China
    2School of Pharmacy, Naval Medical University, Shanghai 200433, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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