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Outline
Sepsis is a life-threatening organ dysfunction caused by infection-induced dysregulation of the host response. Its pathological mechanism is complex, involving excessive inflammatory response, immunosuppression and oxidative stress. Current clinical treatments mainly rely on anti-infection and supportive strategies, but the therapeutic efficacy is limited and the mortality remains high. Traditional Chinese medicine (TCM) monomers show great potential in sepsis treatment due to their multi-target, anti-inflammatory, antioxidant and immunomodulatory properties. Nevertheless, their clinical application is restricted by poor water solubility, low bioavailability and weak targeting ability. As an emerging nanoscale porous material, metal-organic frameworks (MOFs) have become ideal drug delivery carriers for their tunable pore size, high specific surface area and good biocompatibility. This review systematically elaborates the core advantages and mechanisms of MOFs as targeted drug delivery.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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