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Outline
Maintaining intracellular purine nucleotide homeostasis is critical for sustaining normal cellular physiology. Inosine-5′-monophosphate dehydrogenase (IMPDH) acts as the rate-limiting enzyme in the de novo purine nucleotide biosynthesis (DNPNB) pathway, directly regulating intracellular guanine nucleotide synthesis levels. In rapidly proliferating tumor cells, IMPDH is aberrantly activated to meet heightened nucleic acid demands, rendering it a promising target for cancer therapy. Despite the advancement of several candidates — including tiazofurin — into clinical trials, no IMPDH-targeted antitumor drugs have been approved for marketing, highlighting the need for more rigorous and systematic investigation in this field. This review summarizes the structural and functional properties of IMPDH and the progress in developing IMPDH-targeting anticancer drugs, with the aim of providing insights for future research.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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