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Outline
Through repeated application of various chromatographic techniques including silica gel, ODS, MCI, and Sephadex LH-20, 15 compounds were isolated from Magnolia officinalis var. biloba in Lishui. The structures and relative configurations of these compounds were determined using spectroscopic methods such as high-resolution electrospray ionization mass spectroscopy (HRESIMS) and 1D & 2D-NMR. The absolute configurations of compounds (+)-1, (-)-1, (+)-5, and (-)-5 were ultimately established through chiral resolution techniques and quantum chemical calculations of electronic circular dichroism (ECD) spectra. Among these, compounds (+)-1, (-)-1, 2-4, (+)-5, (-)-5, and 6-9 were previously unreported neolignans primarily derived from honokiol or magnolol, while compounds 10-13 were known compounds. The anti-inflammatory activities of all compounds were evaluated using an LPS-induced RAW264.7 cell model. Among them, compound 4 exhibited significant inhibitory activity against nitric oxide (NO) production, with an IC50 value of 1.23 ± 0.04 μmol·L-1.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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