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Outline
Traumatic brain injury (TBI) is a common neurological disorder characterized by high incidence, disability, and mortality rates, posing a substantial global health burden and socioeconomic burden. The complexity of its pathology and the scarcity of effective clinical treatments present significant challenges for drug development. Various animal and in vitro models have been established to simulate TBI and its pathological sequelae, serving as essential tools for mechanistic exploration and drug discovery. This article provides a systematic review of the non-clinical evaluation framework for TBI, including the establishment of common models and key behavioral and molecular pharmacodynamic endpoints. Furthermore, it proposes several recommendations for standardizing the evaluation strategies of anti-TBI drugs, aiming to offer a structured reference for future research in this field.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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