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Nine sesquiterpenoids were isolated from the dichloromethane fraction of the 95% ethanol extract from the roots of Lindera glauca by using a combination of separation techniques, including silica gel, ODS and Sephadex LH-20 column chromatographies, as well as semi-preparative HPLC. Based on a comprehensive analysis of modern spectroscopic data, such as IR, UV, NMR, HRESIMS and ECD, the structures of isolated compounds were identified as glaucatotone M (1), glaucatotone K (2), glaucatotone G (3), pseudoguaianelactone C (4), pseudoguaianelactone B (5), elema-1,3,11(13)-trien-12-oic acid (6), α-costic acid (7), 3β-hydroxycostic acid (8) and rupestonic acid I (9), respectively. Compound 1 was a new guaiane-type sesquiterpenoid, and compounds 6 and 7 were first reported from the genus Lindera. The inhibitory activity of compounds 1-7 and 9 against both the proliferation of TNF-α-induced rheumatoid arthritis fibroblast-like synoviocytes cell line MH7A and the release of pro-inflammatory cytokines (IL-6 and IL-1β) were evaluated. The results showed that compound 1 had a significant inhibitory effect against TNF-α-induced MH7A cell proliferation and reduced the production of IL-6 and IL-1β effectively.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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