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Outline
Microreactors and related technologies, as key components of continuous manufacturing, offer significant advantages in pharmaceutical production, including enhanced manufacturing flexibility, substantial cost reduction, shortened reaction times, improved production efficiency, environmental sustainability, and strengthened supply chain resilience. They are widely regarded as a core enabling technology for realizing continuous pharmaceutical manufacturing and driving the transformation and upgrading of the pharmaceutical industry. In particular, the integration of microreactors with artificial intelligence and automation technologies has reshaped the traditional large-scale production paradigm of "reactor-production line-manufacturing plant", giving rise to new characteristics such as intelligent controllability, operational flexibility, and mobility, as well as modular and stepwise integration, and on-demand production. This paper systematically reviews the performance characteristics of various types of microreactors in pharmaceutical synthesis and their potential applications in intelligent, continuous pharmaceutical manufacturing. Furthermore, it analyzes the development of intelligent and distributed pharmaceutical synthesis systems enabled by the deep integration of artificial intelligence and chip-based microreactors, aiming to achieve continuous, precise, and emergency-responsive drug production, thereby providing important support for the digitalization and intelligent transformation of pharmaceutical manufacturing.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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