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Study on chemical constituents and activities of ethyl acetate fraction from Morus nigra Branches
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Yu-lan ZHAO1, Wen-qing HUANG2, Jiensi AYAJIANG2, Chang-sheng CHI1, Ydyrys ALIBEK4, Ke-jian PANG1, 3, *, Xin-zhou YANG2, *
Acta Pharmaceutica Sinica | 2026, 61(5) : 1749 - 1756
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Acta Pharmaceutica Sinica | 2026, 61(5): 1749-1756
• Original Articles •
Study on chemical constituents and activities of ethyl acetate fraction from Morus nigra Branches
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Yu-lan ZHAO1, Wen-qing HUANG2, Jiensi AYAJIANG2, Chang-sheng CHI1, Ydyrys ALIBEK4, Ke-jian PANG1, 3, *, Xin-zhou YANG2, *
Affiliations
  • 1College of Pharmacy, Shihezi University, Ministry of Education Key Laboratoy for Xinjinag Phytomedicine Resource and Utilization, Shihezi 832003, China
  • 2College of Pharmacy, South-Central Minzu University, Wuhan 430074, China
  • 3College of Biological Sciences and Technology, Yili Normal University, Yining 835000, China
  • 4Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan
Published: 2026-05-12 doi: 10.16438/j.0513-4870.2025-1296
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The ethyl acetate fraction of the 95% ethanol extract from black mulberry branches was isolated and purified by comprehensive application of chromatographic techniques, including normal-phase silica gel column chromatography, Sephadex LH-20 gel column chromatography, and semi-preparative high-performance liquid chromatography (semi-prep HPLC). Fourteen compounds were obtained, and their structures were identified using modern spectroscopic techniques (UV, IR, MS, NMR). These compounds were identified as nigrasin M (1), nigrasin N (2), sanggenol F (3), sanggenon A (4), nigrasin K (5), nigrasin H (6), petalopurpurenol (7), solophenol D (8), nigragenon A (9), nigragenon I (10), nigragenon J (11), notabilisin A (12), notabilisin C (13), and licoflavone C (14). Among them, compounds 1 and 2 are new flavonoids, while compounds 13 and 14 were isolated from Morus nigra branches for the first time. To evaluate the hypoglycemic potential of compounds 1-13, a glucose uptake assay was performed using an L6 cell model. The results showed that compounds 6, 9, 11, and 12 significantly enhanced glucose uptake in L6 cells, suggesting their potential hypoglycemic activity.

Morus nigra  /  chemical constituent  /  isolation and identification  /  flavonoid  /  glucose uptake
赵玉兰, 黄雯晴, 阿亚江·吉恩斯, 池长圣, 阿里贝克·伊迪里斯, 庞克坚, 杨新洲. 黑桑枝乙酸乙酯部分化学成分及其活性研究. 药学学报, 2026 , 61 (5) : 1749 -1756 . DOI: 10.16438/j.0513-4870.2025-1296
Yu-lan ZHAO, Wen-qing HUANG, Jiensi AYAJIANG, Chang-sheng CHI, Ydyrys ALIBEK, Ke-jian PANG, Xin-zhou YANG. Study on chemical constituents and activities of ethyl acetate fraction from Morus nigra Branches[J]. Acta Pharmaceutica Sinica, 2026 , 61 (5) : 1749 -1756 . DOI: 10.16438/j.0513-4870.2025-1296
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Year 2026 volume 61 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2025-1296
  • Receive Date：2025-11-04
  • Online Date：2026-09-21
  • Published：2026-05-12
Article Data
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History
  • Received：2025-11-04
  • Revised：2026-01-20
Affiliations
    1College of Pharmacy, Shihezi University, Ministry of Education Key Laboratoy for Xinjinag Phytomedicine Resource and Utilization, Shihezi 832003, China
    2College of Pharmacy, South-Central Minzu University, Wuhan 430074, China
    3College of Biological Sciences and Technology, Yili Normal University, Yining 835000, China
    4Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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