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Research progress on the bioactivities and nano-delivery systems of natural plant essential oils
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Hong-xuan CAI, Wei-yi CHENG, Wei-ye REN, Jing-quan CHEN, Li-ting HE, Jia-hui HONG, Ying-hui WEI, Ji-gang PIAO*
Acta Pharmaceutica Sinica | 2026, 61(8) : 2968 - 2979
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Acta Pharmaceutica Sinica | 2026, 61(8): 2968-2979
• Reviews •
Research progress on the bioactivities and nano-delivery systems of natural plant essential oils
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Hong-xuan CAI, Wei-yi CHENG, Wei-ye REN, Jing-quan CHEN, Li-ting HE, Jia-hui HONG, Ying-hui WEI, Ji-gang PIAO*
Affiliations
  • School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China
Published: 2026-08-12 doi: 10.16438/j.0513-4870.2025-1158
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Natural plant essential oils, as secondary metabolites of plants, possess hydrophobicity and volatility, and exhibit a wide range of biological activities, including antibacterial, antioxidant, anti-inflammatory, anti-aging, and antitumor effects. They are considered potential alternatives to chemically synthesized drugs. However, their poor stability and low water solubility limit clinical applications. Nanotechnology, through the construction of delivery systems such as liposomes, nanoemulsions, nanogels, and polymeric nanoparticles, significantly improves the stability, bioavailability, and targeting ability of essential oils, thereby enhancing their pharmacological activity and reducing toxic side effects. This review systematically summarizes the chemical composition, biological activity mechanisms, and recent advances in nanoformulations of natural plant essential oils, with a particular focus on the application strategies and effects of nanodelivery systems in improving essential oil performance. Furthermore, it highlights their translational potential and future development directions in modern medicine.

natural plant essential oil  /  biological activity  /  nanodelivery system  /  chemical composition  /  pharmacological mechanism
蔡宏轩, 程苇钇, 任玮晔, 陈井泉, 何李婷, 洪佳慧, 魏颖慧, 朴寄纲. 天然植物精油的生物活性及纳米递送系统的研究进展. 药学学报, 2026 , 61 (8) : 2968 -2979 . DOI: 10.16438/j.0513-4870.2025-1158
Hong-xuan CAI, Wei-yi CHENG, Wei-ye REN, Jing-quan CHEN, Li-ting HE, Jia-hui HONG, Ying-hui WEI, Ji-gang PIAO. Research progress on the bioactivities and nano-delivery systems of natural plant essential oils[J]. Acta Pharmaceutica Sinica, 2026 , 61 (8) : 2968 -2979 . DOI: 10.16438/j.0513-4870.2025-1158
Year 2026 volume 61 Issue 8
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doi: 10.16438/j.0513-4870.2025-1158
  • Receive Date:2025-09-28
  • Online Date:2026-09-21
  • Published:2026-08-12
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  • Received:2025-09-28
  • Revised:2025-11-26
Affiliations
    School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310000, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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