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Outline
To achieve precise drug delivery responsive to the tumor microenvironment (TME), this study designed and constructed a multifunctional nanotherapeutic system. The system employs spherical manganese dioxide (MnO2) as the core, which is loaded with gold nanoparticles (Au nanoparticles, GNPs) and the chemotherapeutic drug 5-fluorouracil (5-FU). It successfully integrates the near-infrared photothermal effect of GNPs and the responsiveness of MnO2 to high glutathione concentration and acidic pH, enabling on-demand drug release under multiple stimuli. Experimental results demonstrate that the as-constructed MnO2/GNPs@5-FU nano-system exhibits high drug loading capacity, excellent photothermal conversion efficiency, and remarkable TME-dependent drug release behavior. In vitro cell experiments demonstrated that the system, by combining MnO2-mediated chemodynamic therapy and 5-FU chemotherapy, achieved a highly efficient synergistic killing effect against 4T1 tumor cells. This study provides preliminary in vitro experimental evidence and novel insights for the development of intelligent nanodrug delivery platforms for tumor-targeted therapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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