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Research progress on the application of chemical proteomics in the target identification of active components in traditional Chinese medicine
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Ting CAO1, Qi-yue LIN1, Wei-yi HE1, Jin-lin HE1, Zi-hua CHEN1, Qian ZHANG1, Ji-gang WANG1, 2, *, Piao LUO1, *
Acta Pharmaceutica Sinica | 2026, 61(1) : 47 - 57
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Acta Pharmaceutica Sinica | 2026, 61(1): 47-57
• Special Reports: Research Progress and Prospects on the Chemical Biology of Traditional Chinese Medicine •
Research progress on the application of chemical proteomics in the target identification of active components in traditional Chinese medicine
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Ting CAO1, Qi-yue LIN1, Wei-yi HE1, Jin-lin HE1, Zi-hua CHEN1, Qian ZHANG1, Ji-gang WANG1, 2, *, Piao LUO1, *
Affiliations
  • 1Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
  • 2Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2026-01-12 doi: 10.16438/j.0513-4870.2025-1071
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Chemical proteomics is a technology widely used in the discovery of active ingredients in traditional Chinese medicine (TCM) and the identification of their targets, enabling the systematic elucidation of TCM's mechanisms of action. Its core lies in designing specific molecular probes to accurately identify target proteins of active TCM components, providing a theoretical basis for revealing pharmacodynamic material foundations and supporting new drug development. China is rich in herbal medicine resources, yet the specific mechanisms and "scientific validity" of TCM have long faced skepticism and criticism. Due to its high specificity and systematic approach, chemical proteomics has become a key tool in promoting the modernization of TCM research. This review summarizes studies from the past five years on identifying targets of active TCM ingredients using chemical proteomics, analyzing both label-based and label-free methods, and discusses the advantages and limitations of different identification strategies. The aim is to provide methodological references for target identification of active TCM components and contribute to the modernization of TCM research.

chemical proteomics  /  active ingredients of traditional Chinese medicine  /  target identification  /  molecular probe  /  mechanisms of action
曹婷, 林琦越, 何伟仪, 何缙霖, 陈梓铧, 张倩, 王继刚, 罗飘. 化学蛋白组学在中药活性成分靶点鉴定中的应用研究进展. 药学学报, 2026 , 61 (1) : 47 -57 . DOI: 10.16438/j.0513-4870.2025-1071
Ting CAO, Qi-yue LIN, Wei-yi HE, Jin-lin HE, Zi-hua CHEN, Qian ZHANG, Ji-gang WANG, Piao LUO. Research progress on the application of chemical proteomics in the target identification of active components in traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2026 , 61 (1) : 47 -57 . DOI: 10.16438/j.0513-4870.2025-1071
Appendix
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Year 2026 volume 61 Issue 1
344
164
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Article Info
doi: 10.16438/j.0513-4870.2025-1071
  • Receive Date：2025-09-10
  • Online Date：2026-09-21
  • Published：2026-01-12
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History
  • Received：2025-09-10
  • Revised：2025-12-15
Affiliations
    1Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
    2Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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