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Study on the specialized metabolites from the endophytic fungus Cercophora sp. UJN-EF001 in Vaccinium bracteatum
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Jun-jiang LI1, Yin-bo PAN1, Jiang-ning ZHAO2, Yin-yin WANG1, Jun-sheng ZHANG1, *, Hua ZHANG1, *
Acta Pharmaceutica Sinica | 2025, 60(12) : 3758 - 3763
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Acta Pharmaceutica Sinica | 2025, 60(12): 3758-3763
• Original Articles •
Study on the specialized metabolites from the endophytic fungus Cercophora sp. UJN-EF001 in Vaccinium bracteatum
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Jun-jiang LI1, Yin-bo PAN1, Jiang-ning ZHAO2, Yin-yin WANG1, Jun-sheng ZHANG1, *, Hua ZHANG1, *
Affiliations
  • 1School of Biological Science and Technology, University of Jinan, Jinan 250022, China
  • 2Qingdao Municipal Hospital, Qingdao 266011, China
Published: 2025-12-12 doi: 10.16438/j.0513-4870.2025-1025
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Thirteen compounds (1-13) were isolated from the ethanol extract of an endophytic fungus Cercophora sp. UJN-EF001 derived from Vaccinium bracteatum, using normal-phase silica gel column chromatography (CC), reversed-phase C18 CC and high-performance liquid chromatography. The structures of these isolates were elucidated through spectroscopic methods including high-resolution mass spectrometry, nuclear magnetic resonance and electronic circular dichroism. Among them, two (1 and 2) were previously unreported molecules, two (3 and 4) were obtained for the first time as natural products, and nine (5-13) were isolated for the first time from the genus Cercophora. All 13 compounds were evaluated for their inhibitory activities against α-glucosidase and nitric oxide (NO) production. As a result, none of them exhibited significant inhibition toward α-glucosidase, while compound 13 displayed moderate inhibition against lipopolysaccharide-induced release of NO in RAW264.7 macrophages with an IC50 value of 34.3 ± 3.8 μmol·L-1.

endophytic fungi  /  Cercophora  /  Vaccinium bracteatum  /  anti-inflammatory activity
李俊江, 潘银波, 赵江宁, 王荫荫, 张君生, 张华. 南烛内生真菌Cercophora sp. UJN-EF001的次级代谢产物研究. 药学学报, 2025 , 60 (12) : 3758 -3763 . DOI: 10.16438/j.0513-4870.2025-1025
Jun-jiang LI, Yin-bo PAN, Jiang-ning ZHAO, Yin-yin WANG, Jun-sheng ZHANG, Hua ZHANG. Study on the specialized metabolites from the endophytic fungus Cercophora sp. UJN-EF001 in Vaccinium bracteatum[J]. Acta Pharmaceutica Sinica, 2025 , 60 (12) : 3758 -3763 . DOI: 10.16438/j.0513-4870.2025-1025
Appendix
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Year 2025 volume 60 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2025-1025
  • Receive Date：2025-08-28
  • Online Date：2026-09-20
  • Published：2025-12-12
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History
  • Received：2025-08-28
  • Revised：2025-10-23
Affiliations
    1School of Biological Science and Technology, University of Jinan, Jinan 250022, China
    2Qingdao Municipal Hospital, Qingdao 266011, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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