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Outline
Phenolic and flavonoid glycosides have the multi-target regulatory advantages in anti-colitis. Using lactose and galactose as starting materials, five novel phenolic glycosides G-6a, G-6b, G-9, G-13 and G-Ⅱ-3a were synthesized through glycosylation, hydrolysis, reduction, and recrystallization. Using a mouse colitis model induced by dextran sulfate sodium, animal experiments have been approved by the Animal Ethics Committee of Ocean University of China (approval number: OUC-SMP-2024-06-05), the in vivo anti-colitis experiments showed that compound G-Ⅱ-3a exhibited significant anti-colitis effects at a daily dose of 25 mg·kg-1, effectively inhibiting weight loss in mice, reducing disease activity index scores, alleviating colonic shortening, maintaining the integrity of colonic mucosal structure, and reducing inflammatory cell infiltration. Its anti-inflammatory effect is superior to mesalazine. G-Ⅱ-3a can inhibit the release of inflammatory factors IL-6, TNF-α, and NO from lipopolysaccharide induced mouse monocyte macrophages RAW264.7. Compound G-Ⅱ-3a is a potential lead compound for the treatment of inflammatory bowel disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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