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Two new glycosides and their anti-pneumonia activities of Ephedra intermedia
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Ying NIU1, 2, Yan-ling LIU1, 2, Yan-gang CAO1, 2, Meng-die LUO1, 2, Xu CHEN1, 2, Hui CHEN1, 2, Xiao-ke ZHENG1, 2, 3, Wei-sheng FENG1, 2, 3, *
Acta Pharmaceutica Sinica | 2026, 61(3) : 854 - 859
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Acta Pharmaceutica Sinica | 2026, 61(3): 854-859
• Original Articles •
Two new glycosides and their anti-pneumonia activities of Ephedra intermedia
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Ying NIU1, 2, Yan-ling LIU1, 2, Yan-gang CAO1, 2, Meng-die LUO1, 2, Xu CHEN1, 2, Hui CHEN1, 2, Xiao-ke ZHENG1, 2, 3, Wei-sheng FENG1, 2, 3, *
Affiliations
  • 1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
  • 3Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Zhengzhou 450046, China
Published: 2026-03-12 doi: 10.16438/j.0513-4870.2025-0984
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A systematic study of the chemical constituents of the n-butanol extraction of Ephedra intermedia (E. intermedia) was carried out and 15 compounds were isolated using various column chromatography combinations with modern wave spectroscopy. Their structures were identified as (7R, 8S, 7′R, 8′S, 7″R, 8″S)-ephnan A (1), 4-methoxy garcimangosone D (2), garcimangosone D (3), (+)-syringaresinol (4), (+)-syringaresinol-O-β-D-glucopyranoside (5), methyl benzoate-4-β-glucoside (6), 3-methoxy-4-O-β-D-glucopyranosyloxy-benzoic acid methyl ester (7), methyl syringate 4-O-β-D-glucopyranoside (8), trans-4-O-β-D-glucopyranosyl ferulic acid (9), 3, 5-dimethoxy-4-O-β-D-glucopyranosyl-cinnamic acid (10), raspberry ketone O-β-D-glucopyranoside (11), E-melilotoside (12), β-D-glucopyranosyl-benzoate (13), 3, 4-dihydroxybenzoic acid 3-O-β-D-glucoside (14), 3, 5-dihydroxy-4-O-β-D-glucopyranosyl acetophenone (15). Compounds 1 and 2 were new compounds, compounds 6-9 and 13-15 were isolated from Ephedra for the first time. Compounds 7, 11-14 exhibited potential anti-pneumonia activity.

Ephedra intermedia  /  n-butanol extraction  /  glycoside  /  structural identification  /  anti-pneumonia activity
牛莹, 刘晏灵, 曹彦刚, 罗梦蝶, 陈旭, 陈辉, 郑晓珂, 冯卫生. 中麻黄中2个新苷类化合物及其抗肺炎活性. 药学学报, 2026 , 61 (3) : 854 -859 . DOI: 10.16438/j.0513-4870.2025-0984
Ying NIU, Yan-ling LIU, Yan-gang CAO, Meng-die LUO, Xu CHEN, Hui CHEN, Xiao-ke ZHENG, Wei-sheng FENG. Two new glycosides and their anti-pneumonia activities of Ephedra intermedia[J]. Acta Pharmaceutica Sinica, 2026 , 61 (3) : 854 -859 . DOI: 10.16438/j.0513-4870.2025-0984
Year 2026 volume 61 Issue 3
183
79
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doi: 10.16438/j.0513-4870.2025-0984
  • Receive Date:2025-08-18
  • Online Date:2026-09-21
  • Published:2026-03-12
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  • Received:2025-08-18
  • Revised:2025-10-27
Affiliations
    1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
    3Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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