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A new neuroprotective isocoumarin from the marine-derived fungus Phaeosphaeriopsis sp. WP-26
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Ying WANG, Li-man ZHOU, Kun LENG, Cong WANG, Pei WANG*
Acta Pharmaceutica Sinica | 2026, 61(4) : 1294 - 1300
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Acta Pharmaceutica Sinica | 2026, 61(4): 1294-1300
• Original Articles •
A new neuroprotective isocoumarin from the marine-derived fungus Phaeosphaeriopsis sp. WP-26
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Ying WANG, Li-man ZHOU, Kun LENG, Cong WANG, Pei WANG*
Affiliations
  • Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Engineering Research Center of Low-Carbon and High-Quality Utilization of Forest Biomass, University of Guangxi, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
Published: 2026-04-12 doi: 10.16438/j.0513-4870.2025-0951
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To further clarify the neuroprotective active components of the marine-derived fungus Phaeosphaeriopsis sp. WP-26, the extract from its rice medium fermentation product was isolated and purified using various column chromatography techniques and high-performance liquid chromatography (HPLC). Nine compounds, including 5 isocoumarin monomers and 4 isocoumarin dimers, were isolated from the extract of the fermentation product of Phaeosphaeriopsis sp. WP-26. The chemical structures of the compounds were elucidated via NMR experiments, high-resolution mass spectrometry analysis, X-ray diffraction analysis, and comparison with the literature. Their structures were identified as phaeosphaerin F (1), 4-chloro-6, 8-dihydroxy-3-methylisochroman-1-one (2), 6-demethylkigelin (3), (3R)-6, 7-dimethoxymellein (4), lignicol (5), spegazmarin C (6), spegazmarin D (7), spegazmarin E (8), and spegazmarin F (9). Among them, compound 1 is a new isocoumarin derivative, and compounds 2, 6-9 were isolated from fungi of the genus Phaeosphaeriopsis for the first time. Compounds 1-9 exhibited neuroprotective effects to varying degrees against H2O2-induced SH-SY5Y cell damage.

marine-derived fungus  /  Phaeosphaeriopsis  /  isocoumarin  /  isocoumarin dimer  /  neuroprotective activity
王颖, 周丽曼, 冷坤, 王聪, 王佩. 海洋拟暗球腔菌Phaeosphaeriopsis sp. WP-26中的一个新异香豆素及其神经保护活性. 药学学报, 2026 , 61 (4) : 1294 -1300 . DOI: 10.16438/j.0513-4870.2025-0951
Ying WANG, Li-man ZHOU, Kun LENG, Cong WANG, Pei WANG. A new neuroprotective isocoumarin from the marine-derived fungus Phaeosphaeriopsis sp. WP-26[J]. Acta Pharmaceutica Sinica, 2026 , 61 (4) : 1294 -1300 . DOI: 10.16438/j.0513-4870.2025-0951
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Year 2026 volume 61 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2025-0951
  • Receive Date：2025-08-12
  • Online Date：2026-09-21
  • Published：2026-04-12
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  • Received：2025-08-12
  • Revised：2025-12-08
Affiliations
    Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Engineering Research Center of Low-Carbon and High-Quality Utilization of Forest Biomass, University of Guangxi, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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