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Outline
Stem cell-like memory T cells (TSCM), a subpopulation of T cells that combines features of both memory cells and stem cells, are capable of rapidly secreting immune cytokines and differentiating into effector T cells with tumor-killing ability after antigenic stimulation, thereby providing a lasting impetus for the anti-tumor immune response. Therefore, inducing TSCM generation to bolster T cells' resistance to exhaustion, thereby improving tumor immunotherapy efficacy, has emerged as a major research focus. Nano-based drug delivery system (NDDS) possesses the qualities of in vivo targeted delivery and facilitated drug penetration, which provides the potential feasibility of inducing TSCM strategy for clinical application. Based on this, this paper systematically describes the characteristics of TSCM, reviews the current regulatory methods to induce and maintain TSCM function, and summarizes the research progress of nano-based drug delivery system in regulating TSCM for anti-tumor therapy, to provide reference and ideas for the application of induced TSCM generation strategies in the clinic.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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