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Research progress on novel drug delivery systems for chemoradiotherapy-induced oral mucositis
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Jiao LUO1, Chao-yu WANG1, Qi-xuan KUANG1, Xue-ke LI1, Xi FU1, Yi-fang JIANG1, Chuan ZHENG1, 2, 3, Feng-ming YOU1, 2, 3, *
Acta Pharmaceutica Sinica | 2026, 61(4) : 1134 - 1142
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Acta Pharmaceutica Sinica | 2026, 61(4): 1134-1142
• Reviews •
Research progress on novel drug delivery systems for chemoradiotherapy-induced oral mucositis
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Jiao LUO1, Chao-yu WANG1, Qi-xuan KUANG1, Xue-ke LI1, Xi FU1, Yi-fang JIANG1, Chuan ZHENG1, 2, 3, Feng-ming YOU1, 2, 3, *
Affiliations
  • 1TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
  • 2Oncology Teaching and Research Department, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
  • 3Institute of Oncology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
Published: 2026-04-12 doi: 10.16438/j.0513-4870.2025-0812
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Oral mucositis (OM) is a common complication of radiotherapy and chemotherapy in cancer patients. The severe pain and ulcer caused by OM not only significantly impair patients' quality of life but may also lead to the interruption of antitumor therapy. Currently, topical drug administration remains the preferred strategy for the prevention and treatment of OM. However, conventional dosage forms (e.g., mouthwash, gel) are susceptible to salivary clearance, exhibiting pharmacokinetic limitations such as short mucosal retention time and rapid drug clearance. In recent years, novel drug delivery systems, including nanocarrier, microneedle and hydrogel, have demonstrated significant advantages in enhancing mucosal drug targeting and prolonging therapeutic duration due to their excellent biocompatibility and controlled release properties. This review summarizes the recent research progress of the above three drug delivery systems in the prevention and treatment of OM, discusses current challenges faced by advanced delivery technologies, and outlines future research directions, aiming to provide insights for the development of more effective therapeutic strategies for OM.

oral mucositis  /  novel drug delivery system  /  nanocarrier  /  microneedle  /  hydrogel
罗娇, 王朝雨, 旷歧轩, 李雪珂, 付西, 蒋义芳, 郑川, 由凤鸣. 新型载药系统在放化疗性口腔黏膜炎防治中的研究进展. 药学学报, 2026 , 61 (4) : 1134 -1142 . DOI: 10.16438/j.0513-4870.2025-0812
Jiao LUO, Chao-yu WANG, Qi-xuan KUANG, Xue-ke LI, Xi FU, Yi-fang JIANG, Chuan ZHENG, Feng-ming YOU. Research progress on novel drug delivery systems for chemoradiotherapy-induced oral mucositis[J]. Acta Pharmaceutica Sinica, 2026 , 61 (4) : 1134 -1142 . DOI: 10.16438/j.0513-4870.2025-0812
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Year 2026 volume 61 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2025-0812
  • Receive Date：2025-07-12
  • Online Date：2026-09-21
  • Published：2026-04-12
Article Data
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History
  • Received：2025-07-12
  • Revised：2025-11-16
Affiliations
    1TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
    2Oncology Teaching and Research Department, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
    3Institute of Oncology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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