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Outline
Resveratrol (Res), a naturally non-flavonoid polyphenol, shows significant therapeutic potential in suppressing tumor growth, metastasis, and enhancing chemotherapy. However, Res has some disadvantages that limit its clinical use, such as low oral bioavailability, structural instability, and non-selective tissue distribution in vivo. Stimuli-responsive drug delivery systems can overcome these issues, achieving efficient delivery in vivo and controlled release at tumor-site. Based on the endogenous physiological features of tumors and exogenous stimulation methods, this paper uses Res as an example, which reviews the current response release methods for targeted delivery of anti-tumor drugs, such as pH, ROS, and light-responsive strategies, respectively. The diversified release designs offer references for controlled release of anti-tumor drugs in the complex tumor microenvironment. It also provides new ideas and directions for personalized and smart treatment for anti-tumor active ingredients from traditional Chinese medicine.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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