Full
Outline
In recent years, the research of transdermal drug delivery systems (TDDS) represented by patches and gel plasters is in the ascendant. The interactions between drugs, pressure-sensitive adhesives, permeation enhancers and skin components, including hydrogen bonds, ionic interactions, dipole-dipole interactions, etc., play a key role in regulating the release and penetration of drugs in transdermal patches, thus affecting the efficiency of transdermal absorption of drugs. Infrared spectroscopy, molecular simulations or molecular docking, differential scanning calorimetry, Raman spectroscopy, nuclear magnetic resonance and other methods have been widely used to characterize multiple intermolecular interactions in patches. The aim of this review is to summary the molecular mechanisms of drug release from patches and transdermal permeation processes, provide useful theoretical guidance for the design and research of novel transdermal drug delivery systems.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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