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Outline
Disruption of protein homeostasis is a central pathological mechanism in a variety of major diseases. However, traditional small-molecule inhibitors are often limited by issues such as undruggable targets and drug resistance, falling short of clinical needs. Targeted protein degradation (TPD) technologies offer a promising alternative by eliminating pathogenic proteins and thus overcoming key bottlenecks in conventional drug development. Among these, proteolysis-targeting chimera (PROTAC), which hijack the ubiquitin–proteasome system to degrade target proteins, have shown significant translational potential in the treatment of cancer and immune-related disorders. To further enhance the specificity and therapeutic index of PROTAC, bioorthogonal strategies have been increasingly explored in recent years for the development of next-generation degraders. These approaches not only reduce systemic toxicity but also enable spatiotemporal precision control, offering new avenues for the rational design of PROTAC.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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