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Outline
In this study, we employed astragalus polysaccharides (APS), derived from the traditional Chinese medicine Astragalus, as a natural carrier, and curcumol (CUL), a hydrophobic component with antitumor activity in the traditional Chinese medicine Curcuma longa, as a model drug, to construct a drug-loaded integrated nanoimmune drug delivery system, CUL@AHNP, and systematically evaluate its in vitro properties, oral absorption properties, and antitumor immune activity. The CUL@AHNP was prepared by high-pressure homogenization, resulting in a particle size of approximately 116.4 nm. It exhibited a spherical structure, a negatively charged surface, and good dispersion and stability. In vitro experiments demonstrated that CUL@AHNP could significantly enhance the inhibitory effect of CUL on breast cancer 4T1 cells and effectively induce immunogenic cell death (ICD) and activate anti-tumor immune responses. Assays measuring cellular uptake and tumor sphere penetration verified the sub stance's excellent transmembrane transport and tissue penetration ability. In vivo studies demonstrated that the oral administration of CUL@AHNP led to a substantial inhibition of tumor growth and an enhancement in the infiltration density of CD8+ and CD4+ T cells. The combination of CUL@AHNP and the chemotherapeutic drug doxorubicin (DOX) exhibited a certain degree of synergistic antitumor effect, without causing significant liver or kidney toxicity. All animal experiments had been approved by the Experimental Animal Ethics Committee of Tianjin University of Traditional Chinese Medicine (No. 2023114). In conclusion, this study constructed an oral nanoimmune drug delivery system based on astragalus polysaccharides, which provides a safer and more efficient therapeutic option for the treatment of breast cancer with traditional Chinese medicine.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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