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Traditional Chinese medicine-derived sporopollenin microcapsules: drug-carrying mechanism, drug delivery applications and their challenges
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Yan-ling LIU1, Xiao-jian LUO1, 2, Xiao-yong RAO1, 2, Xiao-ming FU1, Pei-yu PENG1, Yao ZHANG2, Wei LIU1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(10) : 3036 - 3044
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Acta Pharmaceutica Sinica | 2025, 60(10): 3036-3044
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Traditional Chinese medicine-derived sporopollenin microcapsules: drug-carrying mechanism, drug delivery applications and their challenges
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Yan-ling LIU1, Xiao-jian LUO1, 2, Xiao-yong RAO1, 2, Xiao-ming FU1, Pei-yu PENG1, Yao ZHANG2, Wei LIU1, 2, *
Affiliations
  • 1School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330006, China
  • 2National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China
Published: 2025-10-12 doi: 10.16438/j.0513-4870.2025-0512
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As one of the classic Chinese herbs, spore powder has a long history of medicinal value, not only in terms of therapeutic efficacy, but also through the defatting and removal of the contents can be constructed sporopollenin (SP) cavity structure, which can be used as a highly efficient drug carrier. Compared with synthetic carriers, sporopollenin, as a natural biomaterial, has demonstrated multiple applications in biomedical fields by virtue of its excellent biocompatibility, physicochemical stability, and dimensional homogeneity, and has successfully achieved efficient loading of anti-tumour drugs, proteins, and other active ingredients, and can be further developed into a smart drug delivery system by surface modification technology. In this paper, we summarise the preparation process, loading mechanism, drug delivery system design principle of sporopollenin from traditional Chinese medicine, and its research progress on intelligent drug delivery system, such as targeted delivery and responsive release, and discuss its development prospect, with a view to providing theoretical references and technological support for the promotion of the wide application of traditional Chinese medicine-derived sporopollenin microcapsules in the field of biomedicine.

sporopollenin  /  classification of spore powder  /  the extraction method of sporopollenin  /  the drug loading method of sporopollenin  /  drug loading application
刘艳玲, 罗晓健, 饶小勇, 付小明, 彭佩雨, 张尧, 刘微. 中药衍生孢粉素微胶囊: 载药机制、递药应用及其挑战. 药学学报, 2025 , 60 (10) : 3036 -3044 . DOI: 10.16438/j.0513-4870.2025-0512
Yan-ling LIU, Xiao-jian LUO, Xiao-yong RAO, Xiao-ming FU, Pei-yu PENG, Yao ZHANG, Wei LIU. Traditional Chinese medicine-derived sporopollenin microcapsules: drug-carrying mechanism, drug delivery applications and their challenges[J]. Acta Pharmaceutica Sinica, 2025 , 60 (10) : 3036 -3044 . DOI: 10.16438/j.0513-4870.2025-0512
Year 2025 volume 60 Issue 10
241
114
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Article Info
doi: 10.16438/j.0513-4870.2025-0512
  • Receive Date:2025-05-06
  • Online Date:2026-09-20
  • Published:2025-10-12
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  • Received:2025-05-06
  • Revised:2025-06-13
Affiliations
    1School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330006, China
    2National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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