Full
Outline
From an aqueous extract of the stems with hooks of Uncaria rhynchophylla, eight pairs of scalemic enantiomers of minor lignanoid (+)-/(-)-1 - (+)-/(-)-6、(+)-/(-)-9, and (+)-/(-)-10 as well as two pairs of racemic enantiomers (+)-/(-)-7 and (+)-/(-)-8 were isolated and chirally separated by column chromatographic techniques over macroporous adsorbent resin, MCI resin, Toyopearl HW-40, silica gel, and Sephadex LH-20, together with flash and chiral HPLC techniques. Their structures including the absolute configurations were determined by spectroscopic data analysis and theoretic calculations of electronic circular dichroism (ECD) spectra. Among them, chiral separation and absolute configurational determination of the optical active compounds (+)-/(-)-1 - (+)-/(-)-7 are reported for the first time, while the occurrence of scalemic enantiomers (+)-/(-)-9 and (+)-/(-)-10 in nature are discovered for the first time. Preliminary bioassay showed that (+)-8 and (-)-8 inhibited acetaminophen (APAP) induced HepG2 cell damage at a concentration of 10 μmol·L-1.
313
132
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
