Full
Outline
There exist significant changes in glycosyltransferase expression during tumorigenesis, which leads to the unique sugar chain structural characteristics of glycoproteins on the surface of tumor cells compared to normal cells, namely highly truncated sugar chains. These aberrant glycosylated products are called tumor-associated carbohydrate antigens (tumor-associated carbone antigens, TACAs). As an important molecular marker of malignant tumors, TACAs not only participate in the regulation of tumor occurrence, development, invasion and metastasis of tumors, but also play a key role in tumor immune escape. Thus, targeting abnormally glycosylated proteins or peptides on tumors have become one of most important anti-tumor drug development strategies. However, it is difficult to isolate glycoproteins from natural sources, and it is still challenging to synthesize complex glycoproteins or glycopeptides by chemical methods. This review summarizes the progress of glycopeptide anti-tumor vaccine synthesized by chemical methods in recent years, in order to provide theoretical basis and technical reference for the research and development of glycopeptide anti-tumor vaccine in the future.
361
173
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
