Home Journals Articles Updates About
CN
image
收藏切换
Study on the effect and mechanism of targeted therapy acute myeloid leukemia with supramolecular iron nano gambogic acid
收藏切换
Shang-qin YANG1, 2, Jing-xuan WANG2, 3, Qi-qi XU2, 3, Ming-jie PENG2, 4, Liang-liang LÜ1, 2, Ke-rong TU2, 3, Hong-mei LIU2, 3, Lu-lu CAI1, 2, 3, *, Qiang SUN1, 2, 3, *
Acta Pharmaceutica Sinica | 2025, 60(6) : 1920 - 1929
Less
收藏切换
Acta Pharmaceutica Sinica | 2025, 60(6): 1920-1929
• Original Articles •
Study on the effect and mechanism of targeted therapy acute myeloid leukemia with supramolecular iron nano gambogic acid
Full
Shang-qin YANG1, 2, Jing-xuan WANG2, 3, Qi-qi XU2, 3, Ming-jie PENG2, 4, Liang-liang LÜ1, 2, Ke-rong TU2, 3, Hong-mei LIU2, 3, Lu-lu CAI1, 2, 3, *, Qiang SUN1, 2, 3, *
Affiliations
  • 1School of Pharmacy, Southwest Medical University, Luzhou 646000, China
  • 2Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People′s Hospital, Chengdu 610072, China
  • 3Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China
  • 4College of Pharmacy, Chengdu University, Chengdu 610106, China
Published: 2025-06-12 doi: 10.16438/j.0513-4870.2025-0392
Outline
收藏切换

Acute myeloid leukemia (AML), characterized by rapid progression, therapeutic resistance, and high relapse rates, remains a critical threat to patient survival. The complex leukemic microenvironment often diminishes the efficacy of conventional monotherapies and single-target approaches. Drug delivery strategies based on microenvironment characteristics and multi-mechanism synergy are expected to have better therapeutic effects on AML. Therefore, we developed a biomimetic supramolecular nanoparticle (Fe-GA@CM) through homologous targeting strategy and metal-polyphenol coordination for co-delivery of gambogic acid (GA) and Fe3+. The particle size, zeta potential, and release performance of the system were characterized. Furthermore, the efficacy and mechanism of action of this system in treating AML was explored. The results showed that the particle size of the nano system was approximately 270 nm and positively charged. After being specifically taken up by AML cells, it is reduced by high concentrations of glutathione in the tumor microenvironment and released Fe2+ and GA in a responsive manner. The combination therapy for AML is achieved by inducing ferroptosis with Fe2+ and inhibiting glycolysis in AML cells with GA. In summary, the formulated Fe-GA@CM provides novel ideas for targeted therapy and combination therapy for AML.

acute myeloid leukemia  /  gambogic acid  /  metal-polyphenol coordination  /  ferroptosis  /  glycolysis
杨尚沁, 王静暄, 徐琦琦, 彭明杰, 吕亮亮, 涂柯蓉, 刘红梅, 蔡璐璐, 孙强. 超分子铁螯合藤黄酸靶向治疗急性髓系白血病的作用机制研究. 药学学报, 2025 , 60 (6) : 1920 -1929 . DOI: 10.16438/j.0513-4870.2025-0392
Shang-qin YANG, Jing-xuan WANG, Qi-qi XU, Ming-jie PENG, Liang-liang LÜ, Ke-rong TU, Hong-mei LIU, Lu-lu CAI, Qiang SUN. Study on the effect and mechanism of targeted therapy acute myeloid leukemia with supramolecular iron nano gambogic acid[J]. Acta Pharmaceutica Sinica, 2025 , 60 (6) : 1920 -1929 . DOI: 10.16438/j.0513-4870.2025-0392
Appendix
Less
Year 2025 volume 60 Issue 6
251
123
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2025-0392
  • Receive Date：2025-04-09
  • Online Date：2026-09-20
  • Published：2025-06-12
Article Data
Affiliations
History
  • Received：2025-04-09
  • Revised：2025-05-16
Affiliations
    1School of Pharmacy, Southwest Medical University, Luzhou 646000, China
    2Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People′s Hospital, Chengdu 610072, China
    3Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China
    4College of Pharmacy, Chengdu University, Chengdu 610106, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2025-0392
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House