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Applications of built-in adjuvants in anti-tumor carbohydrate and glycopeptide vaccines
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Ru-yan ZHANG1, Yu WEN2, Wen-xiang ZHAO1, Zhen-hong SU1, Jing-jing DU1, *, Jun GUO2, *
Acta Pharmaceutica Sinica | 2025, 60(7) : 2002 - 2015
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Acta Pharmaceutica Sinica | 2025, 60(7): 2002-2015
• Special Reports: Research progress and development trend of carbohydrate-based vaccines •
Applications of built-in adjuvants in anti-tumor carbohydrate and glycopeptide vaccines
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Ru-yan ZHANG1, Yu WEN2, Wen-xiang ZHAO1, Zhen-hong SU1, Jing-jing DU1, *, Jun GUO2, *
Affiliations
  • 1Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi 435003, China
  • 2International Joint Research Center for Intelligent Biosensing Technology and Health, National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China
Published: 2025-07-12 doi: 10.16438/j.0513-4870.2025-0337
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Carbohydrate and glycopeptide vaccines have shown great promise in tumor prevention and treatment. However, their relatively low immunogenicity remains a significant challenge. To address this, adjuvants are commonly employed to enhance immune responses against specific antigens. Despite their widespread use, conventional adjuvants still face several limitations, including limited immune stimulation and potential safety concerns associated with molecular diffusion. A promising strategy to overcome these challenges is the incorporation of built-in adjuvants, which promotes adjuvants to augment their immunostimulatory effect. This review highlights the application of various immune agonists as built-in adjuvants to enhance vaccine immunogenicity, including Toll-like receptor (TLR) agonists, invariant natural killer T (iNKT) cell agonists, stimulator of interferon genes (STING) agonists, nucleotide-binding oligomerization domain-like receptors (NLR) agonists, and C-type lectin receptor (CLR) agonists. By summarizing recent advancements in this field, we provide valuable insights into the development of more effective and safer carbohydrate vaccines.

anti-tumor vaccine  /  adjuvant-antigen conjugate  /  carbohydrate antigen  /  glycopeptide antigen  /  immunotherapy
张如岩, 文雨, 赵文翔, 苏振宏, 杜晶晶, 郭军. 内嵌佐剂在肿瘤糖疫苗及糖肽疫苗中的应用. 药学学报, 2025 , 60 (7) : 2002 -2015 . DOI: 10.16438/j.0513-4870.2025-0337
Ru-yan ZHANG, Yu WEN, Wen-xiang ZHAO, Zhen-hong SU, Jing-jing DU, Jun GUO. Applications of built-in adjuvants in anti-tumor carbohydrate and glycopeptide vaccines[J]. Acta Pharmaceutica Sinica, 2025 , 60 (7) : 2002 -2015 . DOI: 10.16438/j.0513-4870.2025-0337
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Year 2025 volume 60 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2025-0337
  • Receive Date：2025-03-29
  • Online Date：2026-09-20
  • Published：2025-07-12
Article Data
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History
  • Received：2025-03-29
  • Revised：2025-06-09
Affiliations
    1Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi 435003, China
    2International Joint Research Center for Intelligent Biosensing Technology and Health, National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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