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From targeting DNA replication to disrupting cell division: advances in antibacterial drugs against Gram-negative bacteria
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Run-ying WANG1, 2, Yu-she YANG1, 2, Yin-yong ZHANG2, *
Acta Pharmaceutica Sinica | 2025, 60(12) : 3682 - 3691
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Acta Pharmaceutica Sinica | 2025, 60(12): 3682-3691
• Reviews •
From targeting DNA replication to disrupting cell division: advances in antibacterial drugs against Gram-negative bacteria
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Run-ying WANG1, 2, Yu-she YANG1, 2, Yin-yong ZHANG2, *
Affiliations
  • 1University of Chinese Academy of Sciences, Beijing 100049, China
  • 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Published: 2025-12-12 doi: 10.16438/j.0513-4870.2025-0279
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Due to the unique outer membrane barrier and their complex and diverse multidrug resistance mechanisms, the clinical resistance of Gram-negative bacteria is extremely severe, while the development of related new drugs has progressed slowly. This article systematically reviews representative anti-Gram-negative bacterial drugs that have been marketed in the past decade and those currently in clinical or preclinical research stages. It focuses on introducing drugs with novel targets/mechanisms of action and categorizes them based on intervention strategies targeting key stages of the Gram-negative bacterial life cycle, including: topoisomerase inhibition, protein synthesis disruption, protein transport obstruction, cell wall synthesis inhibition and damage, and bacterial cell division disruption. The content provides a comprehensive review of the structural information, mechanisms of action, antibacterial spectrum, clinical applications, as well as the applicational prospects and challenges of various classes of drugs.

antimicrobial agent  /  Gram-negative bacterium  /  drug resistance  /  antimicrobial mechanism  /  structural optimization
王润瑛, 杨玉社, 张银勇. 从靶向DNA复制到破坏细胞分裂: 抗革兰阴性菌药物研究进展. 药学学报, 2025 , 60 (12) : 3682 -3691 . DOI: 10.16438/j.0513-4870.2025-0279
Run-ying WANG, Yu-she YANG, Yin-yong ZHANG. From targeting DNA replication to disrupting cell division: advances in antibacterial drugs against Gram-negative bacteria[J]. Acta Pharmaceutica Sinica, 2025 , 60 (12) : 3682 -3691 . DOI: 10.16438/j.0513-4870.2025-0279
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Year 2025 volume 60 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2025-0279
  • Receive Date：2025-03-13
  • Online Date：2026-09-20
  • Published：2025-12-12
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  • Received：2025-03-13
  • Revised：2025-04-14
Affiliations
    1University of Chinese Academy of Sciences, Beijing 100049, China
    2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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