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Industrialization breakthroughs in long-acting in situ forming drug delivery systems: key technology platforms, and transformation strategies
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Xin ZHANG1, 2, Gui-zhou HAO2, 3, Xing-hua WANG4, *, Ping-ping SHANG1, 2, 3, *
Acta Pharmaceutica Sinica | 2025, 60(10) : 3008 - 3018
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Acta Pharmaceutica Sinica | 2025, 60(10): 3008-3018
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Industrialization breakthroughs in long-acting in situ forming drug delivery systems: key technology platforms, and transformation strategies
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Xin ZHANG1, 2, Gui-zhou HAO2, 3, Xing-hua WANG4, *, Ping-ping SHANG1, 2, 3, *
Affiliations
  • 1College of Pharmacy, Guilin Medical University, Guilin 541199, China
  • 2Shandong New Time Pharmaceutical Co., Ltd., Linyi 273400, China
  • 3Shandong Complex Injection Engineering Technology Research Center, Linyi 273400, China
  • 4Lunan HOPE Pharmaceutical Co., Ltd., Linyi 276000, China
Published: 2025-10-12 doi: 10.16438/j.0513-4870.2025-0200
Outline
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With the rapid development of contemporary medical technology, long-acting in situ forming preparations have emerged as a pivotal area of investigation in the field of drug delivery. Owing to its unique drug release characteristics, sustained therapeutic effect, enhanced dosing precision and other notable benefits, it represents a transformative approach for clinical treatment. In this study, an in-depth analysis of the characteristics of different technology platforms, the critical technical challenges in the process of industrialization and the emerging trends was conducted through a comprehensive review of products approved by FDA, EMA and other regulatory authorities and the research pipelines global and domestic. The findings aim to provide a strategic framework to support the industrialization of long-acting preparations in China.

long-acting  /  in situ depot-forming system  /  industrialization  /  biodegradable polymer  /  drug delivery
张鑫, 郝贵周, 王兴华, 尚萍萍. 长效原位成型制剂的产业化突破: 关键技术平台与转化战略. 药学学报, 2025 , 60 (10) : 3008 -3018 . DOI: 10.16438/j.0513-4870.2025-0200
Xin ZHANG, Gui-zhou HAO, Xing-hua WANG, Ping-ping SHANG. Industrialization breakthroughs in long-acting in situ forming drug delivery systems: key technology platforms, and transformation strategies[J]. Acta Pharmaceutica Sinica, 2025 , 60 (10) : 3008 -3018 . DOI: 10.16438/j.0513-4870.2025-0200
Year 2025 volume 60 Issue 10
299
140
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Article Info
doi: 10.16438/j.0513-4870.2025-0200
  • Receive Date:2025-02-26
  • Online Date:2026-09-20
  • Published:2025-10-12
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History
  • Received:2025-02-26
  • Revised:2025-06-10
Affiliations
    1College of Pharmacy, Guilin Medical University, Guilin 541199, China
    2Shandong New Time Pharmaceutical Co., Ltd., Linyi 273400, China
    3Shandong Complex Injection Engineering Technology Research Center, Linyi 273400, China
    4Lunan HOPE Pharmaceutical Co., Ltd., Linyi 276000, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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