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Outline
UDP-2, 3-diacylglucosamine pyrophosphate hydrolase (LpxH) is a key enzyme in the lipid A biosynthesis pathway of Gram-negative bacteria. Lipid A is an indispensable component of lipopolysaccharide (LPS), and LPS plays an important biological function in Gram-negative bacteria. Therefore, LpxH is considered one of the important targets in the research of antibacterial drugs. Based on the function and structure of LpxH enzyme, this review systematically summarizes and analyzes the currently reported LpxH inhibitors, and offers perspectives on future research directions. This review will provide ideas for the design of LpxH inhibitors and contribute to the development of new antibacterial drugs targeting LpxH.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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