Full
Outline
In order to clarify the anti-fouling active components of the marine-derived fungal strain Aspergillus terreus GXIMD00546, its fermentation products of the rice medium were isolated by silica gel column chromatography and purified using HPLC. One new compound asperterrestide C (1) and 12 known compounds territrem B (2), methyl-3, 4, 5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate (3), butyrolactone Ⅰ (4), terrien (5), (1R, 2S)-2-hydroxy-5-oxo-3-((E)-prop-1-en-1-yl)cyclopent-3-en-1-yl acetate (6), (1S, 5R)-5-hydroxy-4-oxo-2-((E)-prop-1-en-1-yl)cyclopent-2-en-1-yl acetate (7), 4-hydroxykigelin (8), monacolin K (9), methyl ester of lactone ring-opened monacolin K (10), butyrolactone Ⅶ (11), aspernolide A (12), and epi-aszonalenin C (13) were identified by the detailed data analysis of NMR sepectra, high-resolution mass spectrometry spectra and the comparison with literatures. The new compound asperterrestide C (1) is a cyclopeptide with rare aminomethylation modifications. Compounds 1-3, 6, 7, 9, 11, 12 showed clear anti-fouling activities against the attachment of barnacle larvae in the EC50 ranges of 0.12-12.5 μg·mL-1 with low toxicity. Compounds 1, 2, 4, 9-12 also exhibited acetylcholinesterase inhibitory effects with EC50 range of 17.16-55.77 μg·mL-1. Compounds 4 and 11 have broad spectrum antibacterial activity against human pathogenic bacterium methicillin-resistant Streptococcus aureus (MRSA), and fouling bacteria Methanococcus janaschii (MJ), Vibrio pelagius (VP), and V. Rotiferianus (VR).
204
99
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
