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Research progress on therapeutic targets and drug development for neurodegenerative diseases via modulation of ferroptosis and neuroinflammation
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Zhao-wei LI1, 2, Ling-lei KONG2, *, Xue-mei QIN1, Guan-hua DU2, *
Acta Pharmaceutica Sinica | 2025, 60(5) : 1325 - 1343
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Acta Pharmaceutica Sinica | 2025, 60(5): 1325-1343
• Reviews •
Research progress on therapeutic targets and drug development for neurodegenerative diseases via modulation of ferroptosis and neuroinflammation
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Zhao-wei LI1, 2, Ling-lei KONG2, *, Xue-mei QIN1, Guan-hua DU2, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2025-05-12 doi: 10.16438/j.0513-4870.2025-0032
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Neurodegenerative diseases are one of the leading causes of death and disability worldwide, with complex pathogenesis and lacking effective therapeutic drugs. Increasing researches have shown that most neurodegenerative diseases involve abnormalities in iron homeostasis and activation of immune cells in the brain. Iron accumulation in microglia promotes ferroptosis, leading to cellular dysfunction and death. In contrast, inhibiting ferroptosis can alleviate neuroinflammation, protect neurons, and slow disease progression, highlighting the pivotal roles of ferroptosis and neuroinflammation in neurodegenerative diseases. This review summarizes the roles of ferroptosis and neuroinflammation in neurodegenerative diseases, further discusses the related targets regulating these processes, and reviews the therapeutic potential of drugs targeting ferroptosis and neuroinflammation in neurodegenerative diseases. This review aims to provide novel targets and therapeutic drugs for the treatment of neurodegenerative disease, offering new strategies for clinical management and improving the symptoms and prognosis of neurodegenerative disease.

neurodegenerative disease  /  neuroinflammation  /  ferroptosis  /  inflammatory factor  /  target  /  drug
Zhao-wei LI, Ling-lei KONG, Xue-mei QIN, Guan-hua DU. Research progress on therapeutic targets and drug development for neurodegenerative diseases via modulation of ferroptosis and neuroinflammation[J]. Acta Pharmaceutica Sinica, 2025 , 60 (5) : 1325 -1343 . DOI: 10.16438/j.0513-4870.2025-0032
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Article Info
doi: 10.16438/j.0513-4870.2025-0032
  • Receive Date：2025-01-10
  • Online Date：2025-10-29
  • Published：2025-05-12
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History
  • Received：2025-01-10
  • Revised：2025-02-24
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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