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Tigliane-type diterpenoids are the main active components of croton and a diverse group of macrocyclic diterpenes with diverse biological activities. Their anti-HIV activity have unique advantages and great potential in the treatment of acquired immunodeficiency syndrome (AIDS), and were expected to be developed as a candidate drug for clinical trials of anti-AIDS. This article reviews the research progress on the components of tigliane-type diterpenoids in croton and their anti-HIV activity in recent years, conducts systematic comparisons, summarizes the currently discovered tigliane-type diterpenoids in croton. Their chemical structures and biological activity relationship were summarized. The research progress on the mechanism of tigliane-type diterpenoids' anti-HIV activity was briefly discussed. This research could provide guidance for further development and utilization of coumarin type diterpenes, as well as new ideas for the application of croton.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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