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A new pregnane-type steroid from Munronia unifoliolate Oliv.
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Meng-meng YU1, Yun-peng SUN2, Jun LUO1, *, Ling-yi KONG1, *
Acta Pharmaceutica Sinica | 2025, 60(6) : 1843 - 1846
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Acta Pharmaceutica Sinica | 2025, 60(6): 1843-1846
• Original Articles •
A new pregnane-type steroid from Munronia unifoliolate Oliv.
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Meng-meng YU1, Yun-peng SUN2, Jun LUO1, *, Ling-yi KONG1, *
Affiliations
  • 1School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210000, China
  • 2School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230000, China
Published: 2025-06-12 doi: 10.16438/j.0513-4870.2025-0009
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Using separation methods such as silica gel, MCI, ODS, Sephadex LH-20 gel column chromatography, and high-performance liquid chromatography, two C21 steroid components were isolated and identified from the traditional medicinal plant Munronia unifoliolata Oliv. (commonly known as "Aituotuo"), which is used for treating rheumatic joint pain and traumatic injuries. The structures of these compounds were identified as 2α, 3α, 15β-trihydroxy-20(S)-benzoyl-pregnane (1) and 2α, 3α, 15β-trihydroxy-20(S)-tigloyl-pregnane (2) using comprehensive structural identification methods, including UV, IR, high-resolution mass spectrometry, and one-dimensional and two-dimensional nuclear magnetic resonance. Compounds 1 and 2 were reported for the first time as pregnane-type components from M. unifoliolata, with compound 1 being a new compound. The results of the bioactivity screening indicated that both compound 1 and compound 2 did not inhibit nitric oxide (NO) production and showed no activity in reversing multidrug resistance.

Munronia unifoliolata  /  Aituotuo  /  extraction and isolation  /  pregnane
于萌萌, 孙云鹏, 罗俊, 孔令义. 单叶地黄连中一个新的孕甾烷成分. 药学学报, 2025 , 60 (6) : 1843 -1846 . DOI: 10.16438/j.0513-4870.2025-0009
Meng-meng YU, Yun-peng SUN, Jun LUO, Ling-yi KONG. A new pregnane-type steroid from Munronia unifoliolate Oliv.[J]. Acta Pharmaceutica Sinica, 2025 , 60 (6) : 1843 -1846 . DOI: 10.16438/j.0513-4870.2025-0009
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Year 2025 volume 60 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2025-0009
  • Receive Date：2025-01-04
  • Online Date：2026-09-20
  • Published：2025-06-12
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History
  • Received：2025-01-04
  • Revised：2025-02-20
Affiliations
    1School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210000, China
    2School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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