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Discovery and identification of a new illegal additive: propoxyphenyl hydroxyvardenafil
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Yi-ran LIU1, 2, Hong YU2, Xiao-jing HUANG2, Jing-xian ZHANG2, Ying-ying RAN2, Fan HUANG2, Jian SUN2, *, Qing HU1, 2, Shen JI1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(6) : 1896 - 1900
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Acta Pharmaceutica Sinica | 2025, 60(6): 1896-1900
• Original Articles •
Discovery and identification of a new illegal additive: propoxyphenyl hydroxyvardenafil
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Yi-ran LIU1, 2, Hong YU2, Xiao-jing HUANG2, Jing-xian ZHANG2, Ying-ying RAN2, Fan HUANG2, Jian SUN2, *, Qing HU1, 2, Shen JI1, 2, *
Affiliations
  • 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2Shanghai Institute for Food and Drug Control, National Medical Products Administration Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2025-06-12 doi: 10.16438/j.0513-4870.2024-1304
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A new vardenafil analogue has been discovered in a sexual enhancement health beverage through the application of ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF MS) and high-performance liquid chromatography-diode array detection (HPLC-DAD). This analogue was then purified via preparative HPLC (Prep-HPLC), and its chemical structure was determined using NMR spectroscopy. Spectral data indicated that the vardenafil analogue possesses an n-propyloxy group in place of the ethoxy group on the aromatic ring, and a hydroxyethyl group in substitution for the ethyl group on the piperazine ring. The compound, termed "propoxyphenyl hydroxyvardenafil", has not been reported in China.

propoxyphenyl hydroxyvardenafil  /  PDE-5 inhibitor  /  UHPLC/Q-TOF MS  /  NMR  /  adulteration
刘一冉, 于泓, 黄晓静, 张静娴, 冉莹瑛, 黄帆, 孙健, 胡青, 季申. 新型非法添加物丙氧苯基羟基伐地那非的发现与鉴定. 药学学报, 2025 , 60 (6) : 1896 -1900 . DOI: 10.16438/j.0513-4870.2024-1304
Yi-ran LIU, Hong YU, Xiao-jing HUANG, Jing-xian ZHANG, Ying-ying RAN, Fan HUANG, Jian SUN, Qing HU, Shen JI. Discovery and identification of a new illegal additive: propoxyphenyl hydroxyvardenafil[J]. Acta Pharmaceutica Sinica, 2025 , 60 (6) : 1896 -1900 . DOI: 10.16438/j.0513-4870.2024-1304
Year 2025 volume 60 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2024-1304
  • Receive Date:2024-12-30
  • Online Date:2026-09-20
  • Published:2025-06-12
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  • Received:2024-12-30
  • Revised:2025-03-24
Affiliations
    1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2Shanghai Institute for Food and Drug Control, National Medical Products Administration Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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