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Outline
Ulcerative colitis (UC) is a chronic, non-specific inflammatory disease of the colon that is characterized by complex etiologies, challenging treatment, and high recurrence rate. At present, the main clinical therapeutic agents include suppositories, foams, and liquid enema formulations. But they have problems such as low adhesion and short drug residence time. As a new dosage form, gel has the characteristics of high bioavailability, long drug retention time, high safety and appropriate biological adhesion. This article reviews the relevant literature at home and abroad in the past five years, and analyzes and summarizes the classification of gels, prescription design of various gels, matrix selection, preparation process and pharmacological effects. The results show that the gel can effectively prolong the action time of the drug and alleviate the inflammatory response, which can offer a promising therapeutic strategy for UC management.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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