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A new sesquiterpenes from Pteris wallichiana and its anticancer activity
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Shi-jie REN1, Hong-ke WEI1, Xin-xin CHENG1, Jia-qi WANG2, Xiao-ting QIAO2, Xiao-min WANG2, Zi-yu LÜ1, Duo CAO1, *
Acta Pharmaceutica Sinica | 2025, 60(5) : 1485 - 1489
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Acta Pharmaceutica Sinica | 2025, 60(5): 1485-1489
• Original Articles •
A new sesquiterpenes from Pteris wallichiana and its anticancer activity
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Shi-jie REN1, Hong-ke WEI1, Xin-xin CHENG1, Jia-qi WANG2, Xiao-ting QIAO2, Xiao-min WANG2, Zi-yu LÜ1, Duo CAO1, *
Affiliations
  • 1. Shaanxi Key Laboratory of Research and Utilization of Resource Plants on the Loess Plateau, College of Life Sciences, Yan′an University, Yan′an 716000, China
  • 2. Medical School of Yan'an University, Yan′an 716000, China
Published: 2025-05-12 doi: 10.16438/j.0513-4870.2024-1190
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The methanol extract of Pteris wallichiana was separated and purified by MCI gel, sephadex LH 20, flash C18 and silica gel column chromatography combined with semi-pre HPLC. The chemical structures of the isolated compounds were identified by MS, IR, NMR, etc. Five sesquiterpene compounds were isolated from Pteris wallichiana and identified as 6,7-tetrahydrofuran-(2S, 3S)-pterosin C-3-O-β-D-(6′-acetyl)-Glu (1), (2S, 3S)-pterosin C-3-O-β-D-Glu (2), (2S)-pterosin A (3) and (2S)-13-hydroxyl-pterosin A (4), (2R, 3S)-2-hydroxyl-pterosin C (5). Compound 1 is a new sesquiterpene, compounds 3-5 were isolated for the first time. In vitro bioactivity assay showed that compound 1 was able to inhibit the proliferation of 4T1 and EMT6 cells, and possessed significant anti-triple-negative breast cancer bioactivity.

Pteris wallichiana  /  chemical composition  /  sesquiterpene  /  reactive oxygen species  /  triple negative breast cancer
Shi-jie REN, Hong-ke WEI, Xin-xin CHENG, Jia-qi WANG, Xiao-ting QIAO, Xiao-min WANG, Zi-yu LÜ, Duo CAO. A new sesquiterpenes from Pteris wallichiana and its anticancer activity[J]. Acta Pharmaceutica Sinica, 2025 , 60 (5) : 1485 -1489 . DOI: 10.16438/j.0513-4870.2024-1190
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Year 2025 volume 60 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2024-1190
  • Receive Date：2024-12-03
  • Online Date：2025-10-29
  • Published：2025-05-12
Article Data
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History
  • Received：2024-12-03
  • Revised：2025-02-14
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Affiliations
    1. Shaanxi Key Laboratory of Research and Utilization of Resource Plants on the Loess Plateau, College of Life Sciences, Yan′an University, Yan′an 716000, China
    2. Medical School of Yan'an University, Yan′an 716000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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