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Research progress of plant-derived extracellular vesicles as drug carriers
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Yi-jun LIU1, 2, Hong-juan WANG1, 2, Jing-bin ZHANG2, Huan CHEN1, 2, *, Hong-wei HOU1, 2, *, Qing-yuan HU1, 2
Acta Pharmaceutica Sinica | 2025, 60(3) : 721 - 730
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Acta Pharmaceutica Sinica | 2025, 60(3): 721-730
• Reviews •
Research progress of plant-derived extracellular vesicles as drug carriers
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Yi-jun LIU1, 2, Hong-juan WANG1, 2, Jing-bin ZHANG2, Huan CHEN1, 2, *, Hong-wei HOU1, 2, *, Qing-yuan HU1, 2
Affiliations
  • 1. China National Tobacco Quality Supervision & Test Center, Zhengzhou 450001, China
  • 2. Beijing Life Science Academy, Beijing 102200, China
Published: 2025-03-12 doi: 10.16438/j.0513-4870.2024-1174
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Plant-derived extracellular vesicles (PDEVs) are lipid bilayer-structured nanovesicles secreted by plant cells, recognized as excellent drug carriers due to their high stability, safety, and modifiability. As an emerging drug delivery system, PDEVs are gaining increasing attention. This review systematically summarizes the latest research progress on the preparation, characterization, engineering transformation, drug loading methods, and the applications and advantages of PDEVs as drug carriers. Finally, the future development directions of PDEVs in drug delivery are discussed.

plant-derived extracellular vesicle  /  preparation  /  characterization  /  engineering transformation  /  drug delivery
Yi-jun LIU, Hong-juan WANG, Jing-bin ZHANG, Huan CHEN, Hong-wei HOU, Qing-yuan HU. Research progress of plant-derived extracellular vesicles as drug carriers[J]. Acta Pharmaceutica Sinica, 2025 , 60 (3) : 721 -730 . DOI: 10.16438/j.0513-4870.2024-1174
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Year 2025 volume 60 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2024-1174
  • Receive Date：2024-11-27
  • Online Date：2025-11-06
  • Published：2025-03-12
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History
  • Received：2024-11-27
  • Revised：2025-01-09
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Affiliations
    1. China National Tobacco Quality Supervision & Test Center, Zhengzhou 450001, China
    2. Beijing Life Science Academy, Beijing 102200, China
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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