Home Journals Articles Updates About
CN
image
收藏切换
Proangiogenic and antimicrobial activities of secondary metabolites from the endophytic fungus Penicillium spinulosum
收藏切换
PDF
Wei-lin XU1, Jing LIU1, Jiao FU1, Jun YANG1, Yi-zhen CAO1, Zhi-yong GUO1, 2, Xue-qing ZHANG1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(4) : 1059 - 1063
Less
收藏切换
Acta Pharmaceutica Sinica | 2025, 60(4): 1059-1063
• Original Articles •
Proangiogenic and antimicrobial activities of secondary metabolites from the endophytic fungus Penicillium spinulosum
Full
Wei-lin XU1, Jing LIU1, Jiao FU1, Jun YANG1, Yi-zhen CAO1, Zhi-yong GUO1, 2, Xue-qing ZHANG1, 2, *
Affiliations
  • 1Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
  • 2Key Laboratory of Functional Yeast, China National Light Industry, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
Published: 2025-04-12 doi: 10.16438/j.0513-4870.2024-1116
Outline
收藏切换

A new benzoic acid derivative, spinulacid (1), together with six known compounds ascomindone A (2), ascomindone C (3), monomethylsulochrin (4), barceloneic acid A (5), flufuran (6), and 5-hydroxymethyl-furaldehyde (7) were obtained from the rice fermentation extract of an endophytic fungus Penicillium spinulosum isolated from Emmenopterys henryi Oliv. by various chromatographic techniques. Their structures were elucidated by the analysis of NMR data, MS and comparison with literature. The biological activity results showed that compounds 1, 2, 5, and 6 exhibited significant proangiogenic activity in transgenic zebrafish at concentrations of 20 and 40 μmol·L-1 (the animal experiment was approved by the Animal Ethical and Welfare Committee of Biology Institute, Shandong Academy of Science, the approval number is SWS20240611). Compounds 1 and 4 displayed moderate or strong antifungal activity against phytopathogen Fusarium graminearum with minimum inhibitory concentration (MIC) values of 12.5, and 6.25 μg·mL-1, respectively. Besides, compound 4 was also found to show obvious antibacterial activity against Staphylococcus aureus and Erwinia carotovora with MIC values of 6.25 and 12.5 μg·mL-1, respectively.

endophytic fungus  /  Penicillium spinulosum  /  secondary metabolite  /  proangiogenic activity  /  antifungal activity
Wei-lin XU, Jing LIU, Jiao FU, Jun YANG, Yi-zhen CAO, Zhi-yong GUO, Xue-qing ZHANG. Proangiogenic and antimicrobial activities of secondary metabolites from the endophytic fungus Penicillium spinulosum[J]. Acta Pharmaceutica Sinica, 2025 , 60 (4) : 1059 -1063 . DOI: 10.16438/j.0513-4870.2024-1116
Appendix
Less
Year 2025 volume 60 Issue 4
PDF
117
45
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2024-1116
  • Receive Date：2024-11-10
  • Online Date：2025-10-29
  • Published：2025-04-12
Article Data
Affiliations
History
  • Received：2024-11-10
  • Revised：2024-12-22
Funding
Affiliations
    1Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
    2Key Laboratory of Functional Yeast, China National Light Industry, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2024-1116
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House