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Application and research progress of metal coordination chemistry in the research and development of new drugs of traditional Chinese medicine
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Zhen-na XU1, 2, Hao-ran DING3, Zi-hang XU1, Meng-ru WU1, Ye-han ZHU1, Meng-jiao ZHOU1, Yu-bo LI1, Hui-rong FAN2, *, Ya-qi YAO1, *
Acta Pharmaceutica Sinica | 2025, 60(4) : 919 - 928
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Acta Pharmaceutica Sinica | 2025, 60(4): 919-928
• Reviews •
Application and research progress of metal coordination chemistry in the research and development of new drugs of traditional Chinese medicine
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Zhen-na XU1, 2, Hao-ran DING3, Zi-hang XU1, Meng-ru WU1, Ye-han ZHU1, Meng-jiao ZHOU1, Yu-bo LI1, Hui-rong FAN2, *, Ya-qi YAO1, *
Affiliations
  • 1School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China
  • 3College of Pharmacy, Shandong Xiandai University, Jinan 250154, China
Published: 2025-04-12 doi: 10.16438/j.0513-4870.2024-1111
Outline
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There are abundant resources of traditional Chinese medicine in China, and it is found that the effective components of traditional Chinese medicine contain functional groups that are easy to coordinate with metal ions, such as amino, carboxyl and hydroxyl, which can complex with transition metal ions to derive new compounds. These traditional Chinese medicine metal complexes often exhibit unique properties and functions compared with their corresponding monomers, providing a new path for new drug development. Based on the formation principle of metal complexes with traditional Chinese medicine and the common coordination metal ions, in this review, the effective components in traditional Chinese medicine are roughly divided into anthraquinone, alkaloid, flavone, coumarin, amino acids and polysaccharide compounds, so as to provide new ideas for the discovery of new traditional Chinese medicine, and provide scientific basis for the modernization and internationalization of traditional Chinese medicine.

traditional Chinese medicine  /  natural product  /  coordination chemistry theory  /  metal complex  /  biological activity  /  innovative drug
徐振娜, 丁浩冉, 徐子航, 吴梦茹, 朱叶寒, 周梦娇, 李遇伯, 樊慧蓉, 姚雅琦. 金属配位化学在中药新药研发中的应用及研究进展. 药学学报, 2025 , 60 (4) : 919 -928 . DOI: 10.16438/j.0513-4870.2024-1111
Zhen-na XU, Hao-ran DING, Zi-hang XU, Meng-ru WU, Ye-han ZHU, Meng-jiao ZHOU, Yu-bo LI, Hui-rong FAN, Ya-qi YAO. Application and research progress of metal coordination chemistry in the research and development of new drugs of traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2025 , 60 (4) : 919 -928 . DOI: 10.16438/j.0513-4870.2024-1111
Year 2025 volume 60 Issue 4
897
363
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Article Info
doi: 10.16438/j.0513-4870.2024-1111
  • Receive Date:2024-09-10
  • Online Date:2025-10-29
  • Published:2025-04-12
Article Data
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History
  • Received:2024-09-10
  • Revised:2024-12-20
Funding
Affiliations
    1School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China
    3College of Pharmacy, Shandong Xiandai University, Jinan 250154, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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