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Artificial intelligence-designing drug-loaded bacterial outer membrane vesicles for in vitro activation of dendritic cells
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Dong-xuan XIE1, Yu-hao DONG2, Zhong-gui HE1, 3, Jin SUN1, 3, Meng-chi SUN2, 3, *
Acta Pharmaceutica Sinica | 2025, 60(5) : 1525 - 1533
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Acta Pharmaceutica Sinica | 2025, 60(5): 1525-1533
• Original Articles •
Artificial intelligence-designing drug-loaded bacterial outer membrane vesicles for in vitro activation of dendritic cells
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Dong-xuan XIE1, Yu-hao DONG2, Zhong-gui HE1, 3, Jin SUN1, 3, Meng-chi SUN2, 3, *
Affiliations
  • 1. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 3. Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China
Published: 2025-05-12 doi: 10.16438/j.0513-4870.2024-1107
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Dendritic cells (DCs) play a critical role in both innate and adaptive immunity, particularly in regulating antitumor immune responses. However, immunosuppressive cytokines in the tumor microenvironment and lipid peroxidation imbalance within DCs limit their ability to activate tumor-specific T cells effectively. To address this, we developed a novel biomimetic nanodrug delivery platform using artificial intelligence (AI). This platform encapsulates curcumin nanoparticles in bacterial outer membrane vesicles (OMVs) to enhance DCs function through a dual approach: targeted drug delivery and immune activation. In vitro experiments demonstrated that curcumin reduced lipid peroxidation stress in DCs by modulating the IRE1α-XBP1 signaling pathway, thereby restoring their antigen-presenting function. Additionally, OMVs not only acted as efficient drug carriers but also as immune activators, promoting DCs maturation and enhancing tumor-specific immune responses. This study presents a promising strategy for improving antitumor immunotherapy and offers new insights into the application of AI in drug delivery systems.

artificial intelligence  /  curcumin  /  immunosuppression  /  dendritic cell  /  outer membrane vesicle
Dong-xuan XIE, Yu-hao DONG, Zhong-gui HE, Jin SUN, Meng-chi SUN. Artificial intelligence-designing drug-loaded bacterial outer membrane vesicles for in vitro activation of dendritic cells[J]. Acta Pharmaceutica Sinica, 2025 , 60 (5) : 1525 -1533 . DOI: 10.16438/j.0513-4870.2024-1107
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Article Info
doi: 10.16438/j.0513-4870.2024-1107
  • Receive Date：2024-11-08
  • Online Date：2025-10-29
  • Published：2025-05-12
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History
  • Received：2024-11-08
  • Revised：2024-12-08
Funding
Affiliations
    1. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
    2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    3. Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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