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Research progresses in diagnosis and treatment of myocardial infarction with exosomal microRNA
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Xiao-tong WANG1, Yang-yong DONG1, Ran WANG1, Yu-xuan ZHANG1, Jing-yi CHEN1, Tong-yao WANG1, Xiao-yan QIU2, Xiong XIAO1, *
Acta Pharmaceutica Sinica | 2025, 60(5) : 1285 - 1296
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Acta Pharmaceutica Sinica | 2025, 60(5): 1285-1296
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Research progresses in diagnosis and treatment of myocardial infarction with exosomal microRNA
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Xiao-tong WANG1, Yang-yong DONG1, Ran WANG1, Yu-xuan ZHANG1, Jing-yi CHEN1, Tong-yao WANG1, Xiao-yan QIU2, Xiong XIAO1, *
Affiliations
  • 1. College of Veterinary Medicine, Southwest University, Chongqing 400715, China
  • 2. College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Published: 2025-05-12 doi: 10.16438/j.0513-4870.2024-1093
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Human and animal health will be seriously harmed by myocardial infarction, the diagnostic speed and the therapeutic effect of this disease need to be improved urgently. As the natural carrier for delivering cell information, some microRNAs (miRNAs) found in exosomes can reflect and act on the pathological changes caused by myocardial infarction for effective diagnosis and treatment. The feasibility of exosomal miRNAs (e.g. miR-4516, miR-203, and miR-1915-3p) from different sources as diagnostic agents for myocardial infarction, as well as the research progresses in relief of cell death via apoptosis (e.g. miR-21a-5p, miR-30e, and miR-210), autophagy (e.g. miR-125b-5p, miR-301, and miR-143-3p), pyroptosis (e.g. miR-182-5p, miR-133a, and miR-100-5p), and ferroptosis (e.g. miR-26b-5p and miR-23a-3p), promotion of forming new blood vessels (e.g. miR-29b-3p, miR-210-3p, and miR-494-3p), and inhibition of inflammatory response (e.g. miR-25-3p, miR-182-5p, and miR-671) for intervention therapy of myocardial infarction were reviewed here to provide new strategies for the diagnosis and treatment of myocardial infarction.

exosome  /  microRNA  /  myocardial infarction  /  mechanism  /  diagnosis and treatment
Xiao-tong WANG, Yang-yong DONG, Ran WANG, Yu-xuan ZHANG, Jing-yi CHEN, Tong-yao WANG, Xiao-yan QIU, Xiong XIAO. Research progresses in diagnosis and treatment of myocardial infarction with exosomal microRNA[J]. Acta Pharmaceutica Sinica, 2025 , 60 (5) : 1285 -1296 . DOI: 10.16438/j.0513-4870.2024-1093
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Year 2025 volume 60 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2024-1093
  • Receive Date：2024-11-05
  • Online Date：2025-10-29
  • Published：2025-05-12
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History
  • Received：2024-11-05
  • Revised：2025-01-15
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Affiliations
    1. College of Veterinary Medicine, Southwest University, Chongqing 400715, China
    2. College of Animal Science and Technology, Southwest University, Chongqing 400715, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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