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Advances in drug research targeting ubiquitin-specific protease 7
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Wan-qing YU1, 2, Chao CHEN2, Ya-xi YANG2, Ying ZHI1, Bing ZHOU1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(8) : 2453 - 2465
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Acta Pharmaceutica Sinica | 2025, 60(8): 2453-2465
• Reviews •
Advances in drug research targeting ubiquitin-specific protease 7
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Wan-qing YU1, 2, Chao CHEN2, Ya-xi YANG2, Ying ZHI1, Bing ZHOU1, 2, *
Affiliations
  • 1Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China
  • 2Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China
Published: 2025-08-12 doi: 10.16438/j.0513-4870.2024-1048
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Ubiquitin-specific protease 7 (USP7) is one of the more widely studied members of the deubiquitinating enzyme family, which regulates the activity and function of a variety of proteins in cells. USP7 is closely associated with the tumor progression, which makes USP7 a highly promising target for drug therapy. However, no drug targeting USP7 has yet been approved for clinical trials, thus the development of drug targeting USP7 still requires in-depth research. This article reviews the structure and function of USP7 and the progress of drug research targeting USP7.

ubiquitin-proteasome system  /  deubiquitinase  /  ubiquitin-specific protease 7  /  inhibitor  /  cancer therapy
于万晴, 陈超, 杨亚玺, 智英, 周兵. 靶向泛素特异性蛋白酶7的药物研究进展. 药学学报, 2025 , 60 (8) : 2453 -2465 . DOI: 10.16438/j.0513-4870.2024-1048
Wan-qing YU, Chao CHEN, Ya-xi YANG, Ying ZHI, Bing ZHOU. Advances in drug research targeting ubiquitin-specific protease 7[J]. Acta Pharmaceutica Sinica, 2025 , 60 (8) : 2453 -2465 . DOI: 10.16438/j.0513-4870.2024-1048
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Year 2025 volume 60 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2024-1048
  • Receive Date：2024-10-28
  • Online Date：2026-09-20
  • Published：2025-08-12
Article Data
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History
  • Received：2024-10-28
  • Revised：2024-12-16
Affiliations
    1Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China
    2Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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