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Identification of active hoof nail peptides for wound healing and development of temperature-sensitive gels
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Yi-xin ZHAO1, Ling-zhi LU2, Zai-qing YANG2, Ming-xing WU2, Hao HE2, Xiao-hong YANG2, Ping LIU2, Ping LIN3, Rong-ping YANG1, 2, *, Xiu-mei KE4, *
Acta Pharmaceutica Sinica | 2025, 60(6) : 1930 - 1937
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Acta Pharmaceutica Sinica | 2025, 60(6): 1930-1937
• Original Articles •
Identification of active hoof nail peptides for wound healing and development of temperature-sensitive gels
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Yi-xin ZHAO1, Ling-zhi LU2, Zai-qing YANG2, Ming-xing WU2, Hao HE2, Xiao-hong YANG2, Ping LIU2, Ping LIN3, Rong-ping YANG1, 2, *, Xiu-mei KE4, *
Affiliations
  • 1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 2College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
  • 3College of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
  • 4College of Pharmacy, Chongqing University of Medical Science, Chongqing 400016, China
Published: 2025-06-12 doi: 10.16438/j.0513-4870.2024-1025
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Pig hoof nails represent an underutilized byproduct of pork processing. According to traditional Chinese medical theory, pig hoof nails are believed to contain compounds that may exhibit pharmacological properties such as promoting hemostasis, aiding coagulation, and reducing inflammation, which could potentially benefit the healing of skin wounds. In this study, different molecular masses of hoof nail peptides (HNPs) were extracted from porcine hoof nails. Wound healing assays were employed to identify HNPs that significantly promote fibroblast proliferation and collagen synthesis across three molecular weight ranges: less than 10 kDa (HNP Ⅰ), 3-10 kDa (HNP Ⅱ), and more than 10 kDa (HNP Ⅲ). We formulated HNP Ⅱ into a temperature-sensitive gel designed to conform to uneven wound surfaces. This supports the development and application of hoof nail peptide formulations. The animal operation was approved by the Laboratory Animal Ethics Committee of Southwest University (No: IACUC-20231218-01). All experiments were conducted in accordance with relevant guidelines and regulations.

pig trotter  /  peptide  /  gel  /  wound healing  /  rheological property
赵怡馨, 卢灵芝, 杨再清, 吴明星, 何浩, 杨小红, 刘萍, 林萍, 杨荣平, 柯秀梅. 用于伤口愈合的蹄甲多肽有效组分筛选及温敏凝胶制备研究. 药学学报, 2025 , 60 (6) : 1930 -1937 . DOI: 10.16438/j.0513-4870.2024-1025
Yi-xin ZHAO, Ling-zhi LU, Zai-qing YANG, Ming-xing WU, Hao HE, Xiao-hong YANG, Ping LIU, Ping LIN, Rong-ping YANG, Xiu-mei KE. Identification of active hoof nail peptides for wound healing and development of temperature-sensitive gels[J]. Acta Pharmaceutica Sinica, 2025 , 60 (6) : 1930 -1937 . DOI: 10.16438/j.0513-4870.2024-1025
Appendix
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Year 2025 volume 60 Issue 6
348
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Article Info
doi: 10.16438/j.0513-4870.2024-1025
  • Receive Date：2024-09-10
  • Online Date：2026-09-20
  • Published：2025-06-12
Article Data
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History
  • Received：2024-09-10
  • Revised：2024-12-25
Affiliations
    1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    2College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
    3College of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
    4College of Pharmacy, Chongqing University of Medical Science, Chongqing 400016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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