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Research progress in the pharmacological effects of pungent Chinese medicine based on TRPV channels
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Jia-jia WANG1, Zhi-jun YANG1, 2, 3, *, Xiu-juan YANG1, 2, 3, *, Peng-xian NIU1, Shuo LI1, 2, 3, Guo-jian DUAN1, 2, 3, Yi-hong TIAN1, Qing-yun JI1
Acta Pharmaceutica Sinica | 2025, 60(3) : 679 - 692
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Acta Pharmaceutica Sinica | 2025, 60(3): 679-692
• Reviews •
Research progress in the pharmacological effects of pungent Chinese medicine based on TRPV channels
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Jia-jia WANG1, Zhi-jun YANG1, 2, 3, *, Xiu-juan YANG1, 2, 3, *, Peng-xian NIU1, Shuo LI1, 2, 3, Guo-jian DUAN1, 2, 3, Yi-hong TIAN1, Qing-yun JI1
Affiliations
  • 1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
  • 2. Northwest China-Tibetan Medicine Co-construction and Collaborative Innovation Center, Lanzhou 730000, China
  • 3. Gansu Pharmaceutical Industry Innovation Research Institute, Lanzhou 730000, China
Published: 2025-03-12 doi: 10.16438/j.0513-4870.2024-0997
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Transient receptor potential vanilloid (TRPV), an important class of non-selective cation channels, is closely associated with a variety of physiological and pathological processes. Pungent flavour is one of the important flavours in the doctrine of five flavours in traditional Chinese medicine, which has the functions of relieving the epidermis, moving the Qi, activating the blood and so on, which has a variety of main treatments. Modern research has shown that the active ingredients in numerous pungent Chinese medicine have the ability to modulate TRPV channels. The purpose of paper is to explore the biological characteristics of TRPV channels, the modern research process of pungent Chinese medicine and its mechanism in inflammation, pain and other pathological processes. This paper discusses the research progress of the pharmacological action of pungent Chinese medicine based on TRPV channel, in order to reveal the scientific connotation of spicy traditional Chinese medicine, and also provide new research ideas and models for the modern research of Chinese medicine.

pungent Chinese medicine  /  transient receptor potential vanilloid channel  /  pharmacological action  /  clinical application  /  material basis
Jia-jia WANG, Zhi-jun YANG, Xiu-juan YANG, Peng-xian NIU, Shuo LI, Guo-jian DUAN, Yi-hong TIAN, Qing-yun JI. Research progress in the pharmacological effects of pungent Chinese medicine based on TRPV channels[J]. Acta Pharmaceutica Sinica, 2025 , 60 (3) : 679 -692 . DOI: 10.16438/j.0513-4870.2024-0997
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Year 2025 volume 60 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2024-0997
  • Receive Date：2024-10-15
  • Online Date：2025-11-06
  • Published：2025-03-12
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History
  • Received：2024-10-15
  • Revised：2024-12-20
Funding
Affiliations
    1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
    2. Northwest China-Tibetan Medicine Co-construction and Collaborative Innovation Center, Lanzhou 730000, China
    3. Gansu Pharmaceutical Industry Innovation Research Institute, Lanzhou 730000, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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