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Research development and progress of anti-influenza drug combinations
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Yong-cheng REN1, Bo-yuan YANG2, Jing WANG1, *, Shan CEN1, *
Acta Pharmaceutica Sinica | 2025, 60(4) : 884 - 894
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Acta Pharmaceutica Sinica | 2025, 60(4): 884-894
• Reviews •
Research development and progress of anti-influenza drug combinations
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Yong-cheng REN1, Bo-yuan YANG2, Jing WANG1, *, Shan CEN1, *
Affiliations
  • 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2Shanghai Medical College, Fudan University, Shanghai 200032, China
Published: 2025-04-12 doi: 10.16438/j.0513-4870.2024-0989
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Human influenza is mainly caused by influenza A virus and influenza B virus, and it is one of the most serious infectious diseases that pose a serious threat to human health. Currently, there are few marketed drugs for influenza viruses, and the existing drugs are faced with problems such as drug resistance. The development and research of combinations of anti-influenza drugs have gradually attracted people's attention. At present, certain progress has been made in aspects such as the discovery of anti-influenza drug combinations and the evaluation of drug effects. Discovering effective combination drugs is an ideal method for repurposing old drugs. That can be used to improve therapeutic effects and delay or reduce the occurrence of drug resistance. Herein, this article introduces the evaluation methods, models of combinations of anti-influenza drugs, as well as available data resources and tools, and summarizes the latest progress in the current research on combinations of anti-influenza drugs, with the aim of providing a reference for the research and development of the combined application of anti-influenza virus drugs.

influenza virus  /  drug effect  /  synergistic effect  /  evaluation model  /  drug combination therapy
Yong-cheng REN, Bo-yuan YANG, Jing WANG, Shan CEN. Research development and progress of anti-influenza drug combinations[J]. Acta Pharmaceutica Sinica, 2025 , 60 (4) : 884 -894 . DOI: 10.16438/j.0513-4870.2024-0989
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Year 2025 volume 60 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2024-0989
  • Receive Date：2024-10-12
  • Online Date：2025-10-29
  • Published：2025-04-12
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  • Received：2024-10-12
  • Revised：2024-11-29
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Affiliations
    1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2Shanghai Medical College, Fudan University, Shanghai 200032, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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