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The effect of rutaecarpine on improving fatty liver and osteoporosis in MAFLD mice
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Yu-hao ZHANG1, Yi-ning LI1, Xin-hai JIANG1, 2, Wei-zhi WANG1, Shun-wang LI1, Ren SHENG1, Li-juan LEI1, Yu-yan ZHANG1, Jing-rui WANG1, Xin-wei WEI1, Yan-ni XU1, Yan LIN3, *, Lin TANG4, *, Shu-yi SI1, *
Acta Pharmaceutica Sinica | 2025, 60(1) : 141 - 149
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Acta Pharmaceutica Sinica | 2025, 60(1): 141-149
• Original Articles •
The effect of rutaecarpine on improving fatty liver and osteoporosis in MAFLD mice
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Yu-hao ZHANG1, Yi-ning LI1, Xin-hai JIANG1, 2, Wei-zhi WANG1, Shun-wang LI1, Ren SHENG1, Li-juan LEI1, Yu-yan ZHANG1, Jing-rui WANG1, Xin-wei WEI1, Yan-ni XU1, Yan LIN3, *, Lin TANG4, *, Shu-yi SI1, *
Affiliations
  • 1. Key Laboratory of Biotechnology for Microbial Drugs, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • 3. Beijing Institute of Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
  • 4. China Medico Corporation, Tianjin 300301, China
Published: 2025-01-12 doi: 10.16438/j.0513-4870.2024-0907
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Metabolic-associated fatty liver disease (MAFLD) and osteoporosis (OP) are two very common metabolic diseases. A growing body of experimental evidence supports a pathophysiological link between MAFLD and OP. MAFLD is often associated with the development of OP. Rutaecarpine (RUT) is one of the main active components of Chinese medicine Euodiae Fructus. Our previous studies have demonstrated that RUT has lipid-lowering, anti-inflammatory and anti-atherosclerotic effects, and can improve the OP of rats. However, whether RUT can improve both fatty liver and OP symptoms of MAFLD mice at the same time remains to be investigated. In this study, we used C57BL/6 mice fed a high-fat diet (HFD) for 4 months to construct a MAFLD model, and gave the mice a low dose (5 mg·kg-1) and a high dose (15 mg·kg-1) of RUT by gavage for 4 weeks. The effects of RUT on liver steatosis and bone metabolism were then evaluated at the end of the experiment [this experiment was approved by the Experimental Animal Ethics Committee of Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences (approval number: IMB-20190124D303)]. The results showed that RUT treatment significantly reduced hepatic steatosis and lipid accumulation, and significantly reduced bone loss and promoted bone formation. In summary, this study shows that RUT has an effect of improving fatty liver and OP in MAFLD mice.

rutaecarpine  /  nonalcoholic fatty liver disease  /  metabolic-associated fatty liver disease  /  osteoporosis  /  bone metabolism
Yu-hao ZHANG, Yi-ning LI, Xin-hai JIANG, Wei-zhi WANG, Shun-wang LI, Ren SHENG, Li-juan LEI, Yu-yan ZHANG, Jing-rui WANG, Xin-wei WEI, Yan-ni XU, Yan LIN, Lin TANG, Shu-yi SI. The effect of rutaecarpine on improving fatty liver and osteoporosis in MAFLD mice[J]. Acta Pharmaceutica Sinica, 2025 , 60 (1) : 141 -149 . DOI: 10.16438/j.0513-4870.2024-0907
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Article Info
doi: 10.16438/j.0513-4870.2024-0907
  • Receive Date：2024-09-14
  • Online Date：2025-11-07
  • Published：2025-01-12
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History
  • Received：2024-09-14
  • Revised：2024-10-10
Funding
Affiliations
    1. Key Laboratory of Biotechnology for Microbial Drugs, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
    3. Beijing Institute of Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
    4. China Medico Corporation, Tianjin 300301, China
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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